Business of Biotech: The Bathtub Mechanism (Cancer Research) by John McGowan Ph.D.
7 - 8:30 pm
Cancer is the second leading cause of death in the United States. If
deaths from heart disease continue to decline, cancer is likely to
become the leading cause of death in the future. It is likely between
one in four and one in three readers will die from cancer if current
Cancer is thought to be caused by the accumulation of dozens of
mutations of cancer genes or "oncogenes" and tumor suppressor genes
discovered in the last forty years. This confusing plethora of cancer
genes and the genetic instability that enables cancer cells to adapt to
known anti-cancer drugs presents apparently intractable problems for
current approaches for the cure or effective treatment of most cancers.
In this presentation, Dr. McGowan discusses possible methods to use
systems of "smart drugs" that perform logical or mathematical
calculations inside cells and selectively kill cancer cells using
qualitative features of cancer cells independent of individual oncogenes
and oncoproteins. He will discuss the technical feasibility assessment
of the Bathtub Mechanism, a relatively simple system of three to twelve
drugs that may be able to selectively kill cells with an abnormal number
of chromosomes, a common characteristic of many cancer cells. He will
discuss the technical feasibility assessment of this concept using
computer simulations of cell chemistry and laboratory models such as
yeast. He will discuss the prospects for an open-source and/or
Internet-assisted collaboration of specialists in various areas both to
assess the technical feasibility of the concept -- and other similar
concepts -- and even to actually implement the concept.
John F. McGowan, Ph.D. solves problems using mathematics and mathematical software, including developing video compression and speech recognition technologies. He has a Ph.D. in physics from the University of Illinois at Urbana-Champaign and a B.S. in physics from the California Institute of Technology (Caltech).
Following are some articles of Dr. McGowan's on the subject:
I hope you can join us!