Idealab: Long-term effects of Aβ42 immunisation in Alzheimer’s disease

  • October 2, 2013 · 5:30 PM
  • Ahnon's

Come join IdeaLab, the global DIYbio Journal Club. Every other week, we will be discussing in detail a recent paper from the bioscience literature, with online participants from Counter Culture Labs, BioCurious, Genspace, and other DIYbio groups.

This week, John Schloendorn will be reviewing the following paper:

http://files.meetup.com/8674162/HolmesLancet08.pdf

Long-term effects of Aβ42 immunisation in Alzheimer’s disease: follow-up of a randomised, placebo-controlled phase I trial

Clive Holmes, et al.

Summary: Background Immunisation of patients with Alzheimer’s disease with full-length amyloid-β peptide (Aβ42) can clear amyloid plaques from the brain. Our aim was to assess the relation between Aβ42 immune response, degree of plaque removal, and long-term clinical outcomes.

One claim made in the paper is that patients "with virtually complete plaque removal, had severe end stage dementia." John would like us to discuss this claim, and determine if really supported by the data. If yes, how? If not, what else might the data mean?

Look forward to a wonderful discussion. Please make sure to make a zoom.us account to join the discussion, or join us in person at Ahnon's.

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