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R-related talks

  • Sep 4, 2012 · 7:00 PM
  • Dublin R will be hosting two guest speakers, who will discuss their work with R.
  • The first speaker is Dr Brandon Witchener (Mango Solutions, UK) will present a talk on "Quantitative Medical Image Analysis".
  • The second speaker is Amir Foroushani (Brinkman lab, Simon Fraser University, Canada & Lynn lab, Teagasc, Ireland)
  • The title of this second talk is "Pathway-GPS and SIGORA: Identifying relevant pathways based on the over-representation of their gene-pair signatures."
  • Venue: The seminar room is in Beaux Lane House, on Mercer St, to the rear of the main building and the St Stephen's Green shopping centre.
  • Informal Meetup afterwards at a nearby bar - The Swan on Aungier St - afterwards (about 8.30 approximately)

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  • A former member
    A former member

    Really good!!

    September 5, 2012

  • Kevin O.

    Abstract of Amir's talk:

    Summary of the Talk:

    Over-representation analysis (e.g. using the distribution of hypergeometric probabilities) is a widely used approach for interpreting biological high-throughput experiments: Given a list of genes with observed modified behaviour in a particular disease vs. healthy control , and an ontology describing what higher level processes / 'pathways' (e.g. inflammation, cell cycle) each gene is generally known to engage in, determine which (if any) pathways are statistically enriched among the observed genes and are hence likely to be perturbed/dysregulated in the condition of interest. The idea is that identifying such perturbed pathways might be helpful towards a better understanding of the mechanisms that lead to the disease, or in deciding how to restore the balance by targeting the key regulators of the affected pathways.

    August 21, 2012

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