Ono Academic College Entrepreneurship Club (OnoVation) provides a home for Ono Academic College entrepreneurs and is open to the general public. The club meets monthly and hosts key position holders from the Israeli high-tech industry for lectures. In addition, the monthly meeting creates a platform for Ono Academic College entrepreneurs to present their new start-ups and receive feedback from other club members. At the last three years (2011-2013) Members of OnoVations were the winners of Biztec Business Plan Writing competition at the Technion. The OnoVation Entrepreneurship Club was established and is directed and managed by Dr. Gil Avnimelech, full time faculty member of the Ono Academic College Faculty of Business Administration.
Since 2013, Ono Academic College also has an annual business idea competition - StartOno, which is headed by Mr. Zvika Glikman. In addition, StartOno consult and support entrepreneurs and startups.