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Personalized Medicine and the Omics Revolution

Personalized medicine is expected to benefit from the combination of genomic information with the global monitoring of molecular components and physiological states. To ascertain whether this can be achieved, we determined the whole genome sequence of an individual at high accuracy and performed an integrated Personal Omics Profiling (iPOP) analysis, combining genomic, transcriptomic, proteomic, metabolomic, and autoantibodyomic information, over a 38-month period that included healthy and two virally infected states. Our iPOP analysis of blood components revealed extensive, dynamic and broad changes in diverse molecular components and biological pathways across healthy and disease conditions. Importantly, genomic information was also used to estimate medical risks, including Type 2 Diabetes, whose onset was observed during the course of our study. Our study demonstrates that longitudinal personal omics profiling can relate genomic information to global functional omics activity for physiological and medical interpretation of healthy and disease states.

Meet the speaker, Professor Michael Snyder (Stanford):

Michael Snyder is the Stanford Ascherman Professor, Chair of Genetics and the Director of the Center of Genomics and Personalized Medicine.  He received his Ph.D. from the California Institute of Technology and postdoctoral training at Stanford University.  He is a leader in the field of functional genomics and proteomics, and one of the major participants of the ENCODE project.  His laboratory study was the first to perform a large-scale functional genomics project in any organism, and has launched many technologies in genomics and proteomics. These including the development of proteome chips, high resolution tiling arrays for the entire human genome, methods for global mapping of transcription factor binding sites (ChIP-chip now replaced by ChIP-seq), paired end sequencing for mapping of structural variation in eukaryotes, de novo genome sequencing of genomes using high throughput technologies and RNA-Seq. These technologies have been used for characterizing genomes, proteomes and regulatory networks. Seminal findings from the Snyder laboratory include; the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated, and a high diversity of transcription factor binding occurs both between and within species. He has also combined different state-of–the-art omics technologies to perform the first longitudinal detailed integrative personal omics profile (iPOP) of person and used this to assess disease risk and monitor disease states for personalized medicine. He is a co-founder of several biotechnology companies including; Protometrix (now part of Life Technologies), Affomix (now part of Illumina), Excelix, and Personalis, and he presently serves on the board of a number of companies.


[masked]pm: Registration & Networking (with Food & Beverages sponsored by NetApp)

6:[masked]pm: Introductions

7:00-7:45pm: Talk by Professor Michael Snyder

7:[masked]pm: Q&A session

Join or login to comment.

  • Vernon M.

    Many thanks to the HIVE organizers - Mike gave a very stimulating talk for this crowd - and I am sure he generated new ideas in the healthcare/bioscience arena.

    2 · September 4, 2014

  • Pashu P.

    Professor Snyder's presentation is now available on slideshare: - pictures & video recording coming soon!

    3 · September 4, 2014

  • patrick

    Illuminating after-event discussion on phenotype modeling and the future role of genomics in large scale health/biotech workflows. Snyder is a hell of a domain expert.

    2 · September 3, 2014

  • Jega A

    Great presentation by Michael Snyder. Learnt a lot of stuff about the latest research in Genetics. Micheal had the unique ability to make complex stuff easy to understand. If you missed it make sure you checkout the video recording. Thanks to Hive for making such great presenters available to the community.

    3 · September 3, 2014

  • Dave M.

    What building is this event?

    September 3, 2014

    • Pashu P.

      It is in Building 3!

      September 3, 2014

  • Pashu P.

    See you all at NetApp tonight! Start the conversation online now, tell the world you are attending and start the conversation online using #hivedata

    September 3, 2014

  • Elaine

    Will this be recorded?

    August 19, 2014

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