There is a very spunky, all-female comedy show at the Great American Music Hall this Friday. It's very rare to find a large venue featuring female comics. That's a shame because I love stand up but get tired of guys talking about their junk all the time :). The headliner is Marga Gomez. I've seen her before and she's awesome.
The show is at 9pm, but the doors open at 8, and they serve dinner. The cost is $16. There are plenty of places nearby to hang out afterward.