The fourth 'Sydney Computational Biologists' meetup will feature a talk from Prof. Edgar Wingender, who is visiting from the University of Göttingen, Germany. The talk will take place in the John Shine room, level 6 of the Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst - next to the Garvan Institute for Medical Research. Afterwards, drinks at the nearby Darlo Bar.
Construction and Analysis of Gene Regulatory Networks
Prof. Edgar Wingender
(U. Göttingen, Germany)
In a systems biological view, gene regulatory networks comprising transcriptional and post-transcriptional events may provide a suitable basis to study cellular processes such as cell proliferation, cell differentiation, apoptosis, or tumorigenesis. Using two independent criteria (predicted transcription factor affinity to potential genomic binding sites and multi-genome conservation of such sites), we have constructed the core of a transcriptional network for human cells. This network was expanded (a) by paralogous TF-target gene relations, based on a comprehensive transcription factor classification, and (b) by predicted and known microRNA-target gene relations. From the resulting gene regulatory reference network, a number of tissue-specific subnetworks could be extracted. They revealed structural particularities that seem to be characteristic for the different tissues.
Edgar Wingender is professor and director of the Institute of Bioinformatics of the University Medical Center Göttingen and is CEO of the company geneXplain, which he founded 2010. He started his career as biochemist, before he dedicated himself to bioinformatics since 1993 at the German Research Centre for Biotechnology (GBF). One of his early achievements was the TRANSFAC database on transcriptional regulation. In 1998, he founded the company BIOBASE which he managed from 2001 to 2010. He is also concurrent professor at Nanjing University. He participated in 21 international and national research consortia and has published two books and more than 140 scientific articles.