I can't speak to which is more secure, but tmux is under more active development and has been gaining in popularity. Last screen release: 2008, last tmux release: a few months ago. I find that people I pair with are more often familiar with tmux.
On Friday, June 21, 2013, Sushant Mohanty wrote:
Anyone has thoughts on Screen vs tmux - as a pair-programming dev collaborating tool?
Specially if one is better in security than the other. Screen requires S bit on for multi-user mode to work.
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