There are colloquially two main camps when it comes to Responsive Web Design: fluid web design and adaptive web design. With fluid web design, you start with a fluid grid and add media queries where the design breaks ideally based on your specific content and design. In adaptive web design, you build various sized static designs/layouts usually based on known device sizes.
I'd like to hold this meetup a little bit differently than others. While there are many people who all feel one way is better than another (or think you can, gasp!, use both), I think it'll be more productive to treat this meetup as a group discussion, where we can collectively suss out what works best for each individual. I'll start the meetup with an introduction of the topic, and we can go from there.