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Alzheimer’s Intervention Case Study: Improvements in Memory, Problem Solving, Flexibility, Speed, and Attention.

Ken Russell makes the case for Alzheimer's intervention. Immediately below is a summary, further below is an article on the use of the Alzheimer's intervention protocol (AIP) - read the entire article to better grasp the research that Ken has been doing.

The first therapeutic target of this Alzheimer’s Intervention Protocol (AIP) is a temporary/immediate increase in insulin mediated glucose uptake into the hippo campus for cognition and new memory creation (working memory)

The second therapeutic target of this AIP is the temporary/immediate increase in amino acid uptake in all cells to increase synthesis Cu-Zn Sod1, glutathione, ceruloplasmin and other antioxidants.

The third therapeutic target is the metabolization of the proteinaceous amyloid plaque.

------------ Article: Mark Schwartz was forced out as a “named partner” from his law firm 5 years ago at the age 47. His law partners were required to acknowledge his reduced capacities associated with impaired working memory deficits. Lapses in memory can have devastating consequences in courtroom outcomes which are not likely to be overlooked by any of the participants. Mark soon found himself unable to make a living as successful litigator in the Austin Bar community. Mark began an economic spiral that involved a divorce, a loss of significant contact with four children, a diagnosis of Alzheimer’s pathology and a qualification for Social Security Disability. Mark has spent the last five years living in his mother’s attic with her supervision and maintenance. Mark’s mother is a very capable, competent generous and loving person and a Professor Emeritus at the University of Texas at Austin.

In September of 2012 Mark first logged in on a Lumosity.com website in order to begin a process of challenging his memory functions. His Lumosity.com records suggest that Mark did not actually play any games until October 2012. Mark’s Lumosity Brain Performance Index (BPI) line graph indicates that Mark’s BPI rose to an initial high of 137 and then fluctuated at lower levels until Christmas 2012. On Christmas day Mark received the Alzheimer’s Intervention Protocol (AIP) and began using it to augment the Lumosity.com training experience. Mark’s BPI percentile ranking prior to using the AIP had “flat-lined after 60 days” at .6 percentile (99.4% of the Lumosity.com site participants in the 50-54 age group were exceeding his results). On the first two days of the AIP, Mark’s percentile scores jumped to 5 percentile and then to 10 percentile respectively.

We have previously observed dramatic/immediate/temporary improvements in whole body glucose uptake with T2 diabetics and were not surprised to see dramatic/immediate/temporay improvements in his Lumosity.com scores (we interpret this as evidence of increased glucose uptake into the hippo campus). As of April 29th Mark’s BPI scores have gradually increased to 53.3 percentile and the memory and flexibility sub-components have increased to 62.6 percentile and 63.3 percentile respectively. While these scores must be acknowledged to represent “one off” effects that are subject to “run downs” in the course of each day’s glucose metabolism, there are dramatic improvements in Mark’s demeanor and social presentation that have astounded professionals who deal with AD patients on a daily basis. While Mark has presented Parkinson’s like tremors for about twenty years, a Parkinson’s diagnosis was never made. Mark’s Parkinson’s like tremors have been significantly reduced since starting on the AIP.

It should be noted that in the past year Mark had lost about fifty pounds that might be attributed with swimming approximately one mile per day. The swimming regimen had been discontinued in October 2012. Mark’s Austin physicians had a brain mri done late in 2012 and did not note any shrinkage. A Mayo Clinic M.D.-Ph.D. clinician/researcher has since taken a different position in noting a very small shrinkage. It would seem plausible that Mark’s brain may have been significantly smaller in previous years and the exercise routine was able reverse brain hypometabolism and brain shrinkage.

The first therapeutic target of this Alzheimer’s Intervention Protocol (AIP) is a temporary/immediate increase in insulin mediated glucose uptake into the hippo campus for cognition and new memory creation (woprking memory). We have observed reductions (up to 70%) in post prandial serum glucose spikes of unmedicated Type Two diabetics within thirty minutes of applying the AIP. With the AIP, we have also observed an immediate 20% increase in total body carbohydrate oxidation rates (from aerobic treadmill vo2 and respiration exchange rate analysis). This mechanism of action is the intended therapeutic target for the separate research efforts of William Klein and Suzanne Craft with exogenous insulin delivery. This AIP employs no exogenous insulin, reduces the insulin required by Type One diabetics by half, and is expected to reduce the rate of iron loading via insulin mediated transferrin bound iron. The small population of senior adults who have been using the AIP daily for several years state that the “MCI fog” returns after several days of suspended usage.

The second therapeutic target of this AIP is the temporary/immediate increase in amino acid uptake in all cells to increase synthesis Cu-Zn Sod1, glutathione, ceruloplasmin and other antioxidants. Cu-Zn Sod1 has been identified as the primary target of ROS oxidative damage and the source of cysteine residue associated with the formation of proteinaceous amyloid plaque. Higher levels of glutathione are believed to reduce the oxidation rates of Cu-Zn Sod1 and ceruloplasmin and to reduce the peroxidation rates of polyunsaturated fatty acids into lipofuscin. The lipofuscin immobilizes excess labile iron and reduces the levels of iron that can participate in the ferroportin mediated efflux of iron. Reducing the oxidation rate of serum ceruloplasmin also increases the rate of ferroportin mediated iron efflux from cells by an unknown method. In sum, the intent is to reduce the ROS oxidative damage from lipofuscin bound iron, reduce the level of lipofuscin that can immobilize labile iron, and increase the efflux of excess iron from the brain. Removing the excess iron from the hippo campus will also improve the insulin signaling efficiency (reduced dysregulation of the phospholipid membranes) and the normative uptake of glucose and amino acids.

The third therapeutic target is the metabolization of the proteinaceous amyloid plaque. Case Western researchers have recently employed an Alzheimer’s rodent knockout model to demonstrate that bexarotene enables a retinoid receptor pathway that increases glucose uptake and facilitates the complete elimination of proteinaceous amyloid plaque in three days. The retinoid receptor signaling pathway may be directly downstream from insulin signaling. This hypothesis is supported by the findings that lower ambient insulin levels (lower insulin resistance) is associated with lower levels of Abeta42 in the brain. The fact that the AIP reduces insulin requirements in Type One diabetics by half is cause to suspect that lower insulin levels (lower insulin resistance) may contribute to the elimination of proteinaceous amyloid plaque. A Novel Signaling by Vitamin A/Retinol Promotes Self Renewal of Mouse Embryonic Stem Cells by Activating PI3K/Akt Signaling Pathway via Insulin-Like Growth Factor-1 Receptor†‡§ Liguo Chen, Jaspal S. Khillan,* Article first published online: 4 NOV 2009

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***$20 yearly membership fee required on 3rd meeting.***

We welcome professionals and students alike (Free for students). Come learn about how to serve our community with broader focus and effectiveness. We sincerely desire to build professional, long-lasting relationships for the benefit of our business and clientele.

If you would like to be a speaker, simply let us know and we will see about getting you on the schedule.

Our members are an integrative part of the growing healing community in South Austin including but not limited to: MDs, RNs, PTs, Dentists, Naturopaths, Osteopaths, Chiropractors, Massage Therapists, Acupuncturists, Nutritionists, Doulas, Midwives, Fitness trainers, dance and Zumba instructors, Pilates Instructors, Feldinkras Practitioners, Vocal Coaches, Counselors, Psychotherapists, Psychologists, Energy Healers, Alphabioticists and those who sell health and wellness products, etc.

We welcome professionals and students alike (Free for students). Come learn about how to serve our community with broader focus and effectiveness. We sincerely desire to build professional, long-lasting relationships for the benefit of our business and clientele.

If you would like to be a speaker, simply let us know and we will see about getting you on the schedule.

Format is conducted as follows:

11:45-12:00 Open Meet and Mingle

12:00-12:15 Welcome and Introductory Announcements

12:15-12:45 Table Topic discussion or Presentation on a health subject

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***$20 yearly membership fee required on 3rd meeting***