• Biology Club (Biomakespace): Analysis of Complex Genomic Data

    Title: Analysis of Complex Genomic Data
    Speaker: Harry Blakiston Houston, Co-Founder at The Biotech Podcast,
    PhD researcher (Prof. Ross King's lab) University of Cambridge.

    Over the last decade genome wide association studies have be used to increase our knowledge about the genetic architecture of important traits, from plant traits such as drought resistance to human traits such as diabetes. Optimal analysis of GWAS data is not trivial. Some of the challenges that are faced include; traits that are controlled by a large number of loci called polygenic traits; loci can have effects on multiple phenotypes known as pleiotropy; genetic effects are influenced by external factors that is specific to the environmental context from which the sample was drawn.

    This talk will focus on providing insight into linear mixed effect models and how they are currently used to perform genetic analysis under contributions from polygenicity, pleiotropy and environmental specificity. The speaker will breakdown the models and go through the separate components that make up linear mixed effects models providing an intuitive and somewhat colourful way of looking at these mathematical objects. An additional sneak peek into how researchers have gone about the process of attempting to extend these models to deal with new challenges that go hand in hand with genomic analysis will be discussed. Finally, how once defined these models can be used to uncover new biological knowledge will be explained.

    Biology Club: The Biology Club brings together scientists, engineers, technologists, entrepreneurs, teachers, artists and others interested in engineering with biology at Makespace.
    The Club has talks, social sessions and hands-on practicals or skill-sharing sessions (yes -we have even found some biology and making you can do at home!). If you want to work on biology-related projects, Biomakespace is the section of Makespace for that. It contains experimental biology and fabrication tools focused on scientific
    applications.

    You can join the Biology Club email group at http://biology-club.makespace.org

  • SynBio Forum: Practical Technologies - Low-Cost Microscopes

    Just us for a new series of workshops exploring technologies at the interface of biology, engineering, academia and industry. This series will provide practical advice on how to make the most of the latest biological technologies, and how research can be applied in commercial and non-profit environments.

    -------------------------------------------------------------

    Low-Cost Microscopes

    Dr Richard Bowman - Smart microscopy for everyone with the OpenFlexure Microscope

    Dr Richard Bowman is a Royal Society URF and Proleptic Reader at the University of Bath, who works on lab automation, microscopy, and open source hardware. He has led the OpenFlexure project over the last 6 years, from Friday-afternoon prototype to a well tested design that’s been replicated hundreds of times and is under evaluation for malaria diagnostics in Tanzania. He is passionate about the benefits that smarter equipment can bring to scientific research, particularly when it is coupled with researchers who are able to automate it. He hopes that the hardware and software innovations that make the OpenFlexure microscope a useful research tool will “trickle up” to more expensive and conventional projects, as we move towards a more open and interconnected ecosystem of scientific instruments in our labs.

    Dr Benedict Diederich - UC2 - an open source system for optics (The power in your pocket)

    With UC2 (“You. See. Too”) and “cellSTORM'' the team around Benedict Diederich at the Leibniz Institute for Photonic Technology Jena in Germany have successfully demonstrated that cutting-edge microscopy can be realized for a fraction of the cost of commercial devices using open-source hard- and software. Establishing quality standards and encouraging other researchers to use open-source in their research is one of the key aspects of his research.

    Science lives from the curiosity to solve problems and from subsequent discussion, where scientists exchange knowledge and opinions to come up with new questions. However, as a recent study showed, many published experiments can only be replicated partially, if at all, which contributes to a rising distrust in scientific practice [1].

    The high level of exclusivity of scientific experiments often due to a lack of instruments and knowledge of their use, as well as their high cost, makes it impossible for many researchers to replicate their experiments. Particularly in high-resolution microscopy, which is an essential tool for many disciplines. This problem must be solved if we aim for realistic interdisciplinary scientific exchange. Our ever-growing open-source optical toolbox UC2 ("You.See.Too.") [2] shows that this is not only important but also possible.

    With UC2, we are trying to democratize optics and microscopy. To achieve this, UC2 relies on widely available components and 3D-printed parts so it can be easily built by anyone, anywhere. Through online platforms such as GitHub [3], we enable anyone to use, replicate, and customize it for individual purposes with open-source licenses. Additionally, we invite users from around the world to share their designs with the community to create an iterative and decentralized optimization loop. This way, new collaborations can be created, from education to cutting-edge biology. In the ongoing pandemic, we showed that state-of-the-art microscopic imaging can be realized even where access to equipment is very limited. We were also able to detect and optically resolve the SARS-CoV2 coronavirus in a high-safety biological laboratory.

    The open-source nature of UC2 allows connecting with other open projects to unite the expertise of scientists. By scaling up the production of the UC2-components and organizing interdisciplinary workshops, we hope to lower the entry barriers to get creative with optics and think science easily “out of the box”.

    [1] https://doi.org/10.1038/533452a
    [2] https://doi.org/10.1038/s41467-020-19447-9
    [3] https://github.com/bionanoimaging/UC2-GIT

  • SynBio Forum: Practical Technologies

    Online event

    Just us for a new series of workshops exploring technologies at the interface of biology, engineering, academia and industry. This series will provide practical advice on how to make the most of the latest biological technologies, and how research can be applied in commercial and non-profit environments.

    -------------------------------------------------------------

    The SynBio IRC is pleased to announce a new series of workshops providing practical advice for researchers interested in exploring the latest biological technologies. The workshops will explore how novel technologies can be used to drive research with real-world applications. Sessions will look at both the development of technology and it's transfer into the public realm via both commericialisation and non-profit companies and initiatives.

    The workshops will feature speakers from academia, industry and the non-profit sector, giving insite into the whole lifecycle of application-driven technologies, from ideas and develeopment to being used by consumers. The sessions will showcase different methods used to deliver research outcomes, including spin-outs, non-profit companies and open-access projects.

    Workshops will be held monthly online, Tuesday 3-4:30pm. We hope you are able to join us and are happy to share a preliminary schedule below:

    29th Jun: Open Tools for Bioproduction:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/hvjpksyccjbmc/
    27th Jul: Low-Cost Microscopes:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/xvjpksycckbkc/
    31st Aug: Open Technology Frameworks:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksycclbpc/
    28th Sep: Accessible Automation:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccmblc/
    26th Oct: Soft Robotics:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccnbjc/
    30th Nov: Novel Sensors:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccpbnc/
    14th Dec: Next-Generation Scanning Microscopes:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccqblc/

    -------------------------------------------------------------

    For queries please contact Steph Norwood at [masked].

  • SynBio Forum: Practical Technologies

    Online event

    Just us for a new series of workshops exploring technologies at the interface of biology, engineering, academia and industry. This series will provide practical advice on how to make the most of the latest biological technologies, and how research can be applied in commercial and non-profit environments.

    -------------------------------------------------------------

    The SynBio IRC is pleased to announce a new series of workshops providing practical advice for researchers interested in exploring the latest biological technologies. The workshops will explore how novel technologies can be used to drive research with real-world applications. Sessions will look at both the development of technology and it's transfer into the public realm via both commericialisation and non-profit companies and initiatives.

    The workshops will feature speakers from academia, industry and the non-profit sector, giving insite into the whole lifecycle of application-driven technologies, from ideas and develeopment to being used by consumers. The sessions will showcase different methods used to deliver research outcomes, including spin-outs, non-profit companies and open-access projects.

    Workshops will be held monthly online, Tuesday 3-4:30pm. We hope you are able to join us and are happy to share a preliminary schedule below:

    29th Jun: Open Tools for Bioproduction:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/hvjpksyccjbmc/
    27th Jul: Low-Cost Microscopes:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/xvjpksycckbkc/
    31st Aug: Open Technology Frameworks:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksycclbpc/
    28th Sep: Accessible Automation:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccmblc/
    26th Oct: Soft Robotics:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccnbjc/
    30th Nov: Novel Sensors:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccpbnc/
    14th Dec: Next-Generation Scanning Microscopes:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccqblc/

    -------------------------------------------------------------

    For queries please contact Steph Norwood at [masked].

  • SynBio Forum: Practical Technologies

    Online event

    Just us for a new series of workshops exploring technologies at the interface of biology, engineering, academia and industry. This series will provide practical advice on how to make the most of the latest biological technologies, and how research can be applied in commercial and non-profit environments.

    -------------------------------------------------------------

    The SynBio IRC is pleased to announce a new series of workshops providing practical advice for researchers interested in exploring the latest biological technologies. The workshops will explore how novel technologies can be used to drive research with real-world applications. Sessions will look at both the development of technology and it's transfer into the public realm via both commericialisation and non-profit companies and initiatives.

    The workshops will feature speakers from academia, industry and the non-profit sector, giving insite into the whole lifecycle of application-driven technologies, from ideas and develeopment to being used by consumers. The sessions will showcase different methods used to deliver research outcomes, including spin-outs, non-profit companies and open-access projects.

    Workshops will be held monthly online, Tuesday 3-4:30pm. We hope you are able to join us and are happy to share a preliminary schedule below:

    29th Jun: Open Tools for Bioproduction:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/hvjpksyccjbmc/
    27th Jul: Low-Cost Microscopes:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/xvjpksycckbkc/
    31st Aug: Open Technology Frameworks:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksycclbpc/
    28th Sep: Accessible Automation:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccmblc/
    26th Oct: Soft Robotics:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccnbjc/
    30th Nov: Novel Sensors:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccpbnc/
    14th Dec: Next-Generation Scanning Microscopes:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccqblc/

    -------------------------------------------------------------

    For queries please contact Steph Norwood at [masked].

  • SynBio Forum: Practical Technologies

    Online event

    Just us for a new series of workshops exploring technologies at the interface of biology, engineering, academia and industry. This series will provide practical advice on how to make the most of the latest biological technologies, and how research can be applied in commercial and non-profit environments.

    -------------------------------------------------------------

    The SynBio IRC is pleased to announce a new series of workshops providing practical advice for researchers interested in exploring the latest biological technologies. The workshops will explore how novel technologies can be used to drive research with real-world applications. Sessions will look at both the development of technology and it's transfer into the public realm via both commericialisation and non-profit companies and initiatives.

    The workshops will feature speakers from academia, industry and the non-profit sector, giving insite into the whole lifecycle of application-driven technologies, from ideas and develeopment to being used by consumers. The sessions will showcase different methods used to deliver research outcomes, including spin-outs, non-profit companies and open-access projects.

    Workshops will be held monthly online, Tuesday 3-4:30pm. We hope you are able to join us and are happy to share a preliminary schedule below:

    29th Jun: Open Tools for Bioproduction:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/hvjpksyccjbmc/
    27th Jul: Low-Cost Microscopes:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/xvjpksycckbkc/
    31st Aug: Open Technology Frameworks:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksycclbpc/
    28th Sep: Accessible Automation:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccmblc/
    26th Oct: Soft Robotics:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccnbjc/
    30th Nov: Novel Sensors:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccpbnc/
    14th Dec: Next-Generation Scanning Microscopes:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccqblc/

    -------------------------------------------------------------

    For queries please contact Steph Norwood at [masked].

  • SynBio Forum: Practical Technologies

    Online event

    Just us for a new series of workshops exploring technologies at the interface of biology, engineering, academia and industry. This series will provide practical advice on how to make the most of the latest biological technologies, and how research can be applied in commercial and non-profit environments.

    -------------------------------------------------------------

    The SynBio IRC is pleased to announce a new series of workshops providing practical advice for researchers interested in exploring the latest biological technologies. The workshops will explore how novel technologies can be used to drive research with real-world applications. Sessions will look at both the development of technology and it's transfer into the public realm via both commericialisation and non-profit companies and initiatives.

    The workshops will feature speakers from academia, industry and the non-profit sector, giving insite into the whole lifecycle of application-driven technologies, from ideas and develeopment to being used by consumers. The sessions will showcase different methods used to deliver research outcomes, including spin-outs, non-profit companies and open-access projects.

    Workshops will be held monthly online, Tuesday 3-4:30pm. We hope you are able to join us and are happy to share a preliminary schedule below:

    29th Jun: Open Tools for Bioproduction:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/hvjpksyccjbmc/
    27th Jul: Low-Cost Microscopes:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/xvjpksycckbkc/
    31st Aug: Open Technology Frameworks:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksycclbpc/
    28th Sep: Accessible Automation:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccmblc/
    26th Oct: Soft Robotics:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccnbjc/
    30th Nov: Novel Sensors:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccpbnc/
    14th Dec: Next-Generation Scanning Microscopes:
    https://www.meetup.com/Cambridge-Synthetic-Biology-Meetup/events/qwjpksyccqblc/

    -------------------------------------------------------------

    For queries please contact Steph Norwood at [masked].