Come join IdeaLab, the global DIYbio Journal Club. Every other week, we will be discussing in detail a recent paper from the bioscience literature, with online participants from Counter Culture Labs, BioCurious, Genspace, and other DIYbio groups.
Dan Orr is going to lead us on a discussion of Warshel and Levitt's 1975 Nature article on modeling protein folds, which led to their recent Nobel prize in chemistry:
Computer simulation of protein folding (http://files.meetup.com/8674162/LevittNature75.pdf)
Michael Levitt & Arieh Warshel
A new and very simple representation of protein conformations has been used together with energy minimisation and thermalisation to simulate protein folding. Under certain conditions, the method succeeds in ‘renaturing’ bovine pancreatic trypsin inhibitor from an open-chain conformation into a folded conformation close to that of the native molecule.
Participants can join online via zoom.us ( https://zoom.us/j/491340222 ), or join us in person at Ahnon's.