What we're about

In this era of precision medicine and new diagnostic tools, the Diagnostics World Meetup offers our community a discussion platform on how diagnostics are posed to change the way our illnesses are found, treated, and even defined.

We will meet up in person on a monthly basis so our group members can meet other professionals to discuss challenges and breakthroughs while networking in a social setting. In between our meetups, we will post discussions and webinars to spark conversation among group members.

Upcoming events (5+)

End-to-End Application of UltiMapper Kits for Multiplexed Immuno-Profiling

Hi All! We are hosting another webinar that I believe would be very beneficial to our group. I have included the information below. Let me know if you have any questions. Title: From Staining to Analysis: End-to-End Application of UltiMapper Kits for Multiplexed Immuno-Profiling Register: http://www.bio-itworld.com/ultivue/from-staining-to-analysis/ Webinar Description: Conventional immunohistochemistry (IHC) methods only provide insight into a limited number of markers of interest. With high spatial heterogeneity and biological complexity, resected tumor samples present a significant characterization challenge, particularly when samples are scarce. Multiplexing in a single, intact tissue sample is required to identify cell types, understand biological pathways, and map cellular interactions. The past decade has seen the introduction of multiplexed immunofluorescence to establish the spatial relationships between various immune cells in tumor biology, in context. Histopathologists not only need to detect these multiple cell populations identified by specific protein markers, but also need to determine how they interact spatially, through a complex array of signaling markers. From upstream discovery, down to translational and clinical implementation, this multiplexing in situ need translates into high single-digit, even double-digit numbers of protein markers, to be imaged on single biopsy sections. Addressing this need, especially acute in immuno-oncology, Ultivue provides significant benefits of shorter panel validation, whole slide imaging at higher throughput without requiring dedicated instrumentation. Ultivue has developed a fully optimized, automated staining protocol on the Leica BOND RX platform. Such walkaway automation enables the staining of up to 30 slides per 4 to 5 hour run, with high reproducibility run-to-run and exceptional operator-to-operator consistency. Using our predefined UltiMapperTM I/O 5-plex kits on the BOND RX for research use only, Discovery, Translational and Clinical Research labs can implement easy and convenient multiplexed staining. Avoiding any linear unmixing after image acquisition, the UltiMapper I/O whole slide images are directly analyzed using the IndicaLabs HALO software, to derive cell counts, marker co-localization and proximity data. HALO therefore provides the analytical tools to tap into convoluted biomarker signatures and answer complex biological questions posed by the tumor micro-environment. Learning Objectives Benefits of the Ultivue technology and value proposition of the UltiMapper I/O kits UltiMapper I/O automated workflow on the Leica BOND RX Downstream image analysis using IndicaLabs’ HALO Register for this free informative webinar: http://www.bio-itworld.com/ultivue/from-staining-to-analysis/

End-to-End Application of UltiMapper Kits for Multiplexed Immuno-Profiling

Hi All! We are hosting another webinar that I believe would be very beneficial to our group. I have included the information below. Let me know if you have any questions. Title: From Staining to Analysis: End-to-End Application of UltiMapper Kits for Multiplexed Immuno-Profiling Register: http://www.bio-itworld.com/ultivue/from-staining-to-analysis/ Webinar Description: Conventional immunohistochemistry (IHC) methods only provide insight into a limited number of markers of interest. With high spatial heterogeneity and biological complexity, resected tumor samples present a significant characterization challenge, particularly when samples are scarce. Multiplexing in a single, intact tissue sample is required to identify cell types, understand biological pathways, and map cellular interactions. The past decade has seen the introduction of multiplexed immunofluorescence to establish the spatial relationships between various immune cells in tumor biology, in context. Histopathologists not only need to detect these multiple cell populations identified by specific protein markers, but also need to determine how they interact spatially, through a complex array of signaling markers. From upstream discovery, down to translational and clinical implementation, this multiplexing in situ need translates into high single-digit, even double-digit numbers of protein markers, to be imaged on single biopsy sections. Addressing this need, especially acute in immuno-oncology, Ultivue provides significant benefits of shorter panel validation, whole slide imaging at higher throughput without requiring dedicated instrumentation. Ultivue has developed a fully optimized, automated staining protocol on the Leica BOND RX platform. Such walkaway automation enables the staining of up to 30 slides per 4 to 5 hour run, with high reproducibility run-to-run and exceptional operator-to-operator consistency. Using our predefined UltiMapperTM I/O 5-plex kits on the BOND RX for research use only, Discovery, Translational and Clinical Research labs can implement easy and convenient multiplexed staining. Avoiding any linear unmixing after image acquisition, the UltiMapper I/O whole slide images are directly analyzed using the IndicaLabs HALO software, to derive cell counts, marker co-localization and proximity data. HALO therefore provides the analytical tools to tap into convoluted biomarker signatures and answer complex biological questions posed by the tumor micro-environment. Learning Objectives Benefits of the Ultivue technology and value proposition of the UltiMapper I/O kits UltiMapper I/O automated workflow on the Leica BOND RX Downstream image analysis using IndicaLabs’ HALO Register for this free informative webinar: http://www.bio-itworld.com/ultivue/from-staining-to-analysis/

End-to-End Application of UltiMapper Kits for Multiplexed Immuno-Profiling

Hi All! We are hosting another webinar that I believe would be very beneficial to our group. I have included the information below. Let me know if you have any questions. Title: From Staining to Analysis: End-to-End Application of UltiMapper Kits for Multiplexed Immuno-Profiling Register: http://www.bio-itworld.com/ultivue/from-staining-to-analysis/ Webinar Description: Conventional immunohistochemistry (IHC) methods only provide insight into a limited number of markers of interest. With high spatial heterogeneity and biological complexity, resected tumor samples present a significant characterization challenge, particularly when samples are scarce. Multiplexing in a single, intact tissue sample is required to identify cell types, understand biological pathways, and map cellular interactions. The past decade has seen the introduction of multiplexed immunofluorescence to establish the spatial relationships between various immune cells in tumor biology, in context. Histopathologists not only need to detect these multiple cell populations identified by specific protein markers, but also need to determine how they interact spatially, through a complex array of signaling markers. From upstream discovery, down to translational and clinical implementation, this multiplexing in situ need translates into high single-digit, even double-digit numbers of protein markers, to be imaged on single biopsy sections. Addressing this need, especially acute in immuno-oncology, Ultivue provides significant benefits of shorter panel validation, whole slide imaging at higher throughput without requiring dedicated instrumentation. Ultivue has developed a fully optimized, automated staining protocol on the Leica BOND RX platform. Such walkaway automation enables the staining of up to 30 slides per 4 to 5 hour run, with high reproducibility run-to-run and exceptional operator-to-operator consistency. Using our predefined UltiMapperTM I/O 5-plex kits on the BOND RX for research use only, Discovery, Translational and Clinical Research labs can implement easy and convenient multiplexed staining. Avoiding any linear unmixing after image acquisition, the UltiMapper I/O whole slide images are directly analyzed using the IndicaLabs HALO software, to derive cell counts, marker co-localization and proximity data. HALO therefore provides the analytical tools to tap into convoluted biomarker signatures and answer complex biological questions posed by the tumor micro-environment. Learning Objectives Benefits of the Ultivue technology and value proposition of the UltiMapper I/O kits UltiMapper I/O automated workflow on the Leica BOND RX Downstream image analysis using IndicaLabs’ HALO Register for this free informative webinar: http://www.bio-itworld.com/ultivue/from-staining-to-analysis/

End-to-End Application of UltiMapper Kits for Multiplexed Immuno-Profiling

Hi All! We are hosting another webinar that I believe would be very beneficial to our group. I have included the information below. Let me know if you have any questions. Title: From Staining to Analysis: End-to-End Application of UltiMapper Kits for Multiplexed Immuno-Profiling Register: http://www.bio-itworld.com/ultivue/from-staining-to-analysis/ Webinar Description: Conventional immunohistochemistry (IHC) methods only provide insight into a limited number of markers of interest. With high spatial heterogeneity and biological complexity, resected tumor samples present a significant characterization challenge, particularly when samples are scarce. Multiplexing in a single, intact tissue sample is required to identify cell types, understand biological pathways, and map cellular interactions. The past decade has seen the introduction of multiplexed immunofluorescence to establish the spatial relationships between various immune cells in tumor biology, in context. Histopathologists not only need to detect these multiple cell populations identified by specific protein markers, but also need to determine how they interact spatially, through a complex array of signaling markers. From upstream discovery, down to translational and clinical implementation, this multiplexing in situ need translates into high single-digit, even double-digit numbers of protein markers, to be imaged on single biopsy sections. Addressing this need, especially acute in immuno-oncology, Ultivue provides significant benefits of shorter panel validation, whole slide imaging at higher throughput without requiring dedicated instrumentation. Ultivue has developed a fully optimized, automated staining protocol on the Leica BOND RX platform. Such walkaway automation enables the staining of up to 30 slides per 4 to 5 hour run, with high reproducibility run-to-run and exceptional operator-to-operator consistency. Using our predefined UltiMapperTM I/O 5-plex kits on the BOND RX for research use only, Discovery, Translational and Clinical Research labs can implement easy and convenient multiplexed staining. Avoiding any linear unmixing after image acquisition, the UltiMapper I/O whole slide images are directly analyzed using the IndicaLabs HALO software, to derive cell counts, marker co-localization and proximity data. HALO therefore provides the analytical tools to tap into convoluted biomarker signatures and answer complex biological questions posed by the tumor micro-environment. Learning Objectives Benefits of the Ultivue technology and value proposition of the UltiMapper I/O kits UltiMapper I/O automated workflow on the Leica BOND RX Downstream image analysis using IndicaLabs’ HALO Register for this free informative webinar: http://www.bio-itworld.com/ultivue/from-staining-to-analysis/

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