Biotech paper reading. Perturbation-Conditioned Diffusion Models

Scientific Paper Reading Club: Perturbation-Conditioned Diffusion Models
This is part of the scientific paper reading club.
This Saturday, we will be diving into a fascinating new approach to AI in healthcare and drug discovery. We will be discussing the paper "Reading the Cell, Designing the Cure: Perturbation-Conditioned Molecular Diffusion for Function-Oriented Drug Design".

• Paper (arXiv): https://arxiv.org/abs/2605.15243
• Official GitHub Repository: https://github.com/EdwardCurry/CURE_TBDD

What to expect:
Our presenter, Pavel, is currently working in this field and will be sharing some of his personal thoughts and insights on the topic. He has prepared a short, accessible summary of the paper that requires almost no background in biology, so it will be easy to follow for everyone!
We will explore how the authors use a framework called CURE to rethink drug design. Instead of the traditional "lock-and-key" method that requires knowing the exact 3D protein structures, this model treats drug design as an inverse generation problem—using a diffusion model to generate molecules based purely on the functional cellular state changes (transcriptomic signatures) they need to induce.
Meeting Details:
🗣 Presenter: Pavel Abramov
💬 Language of the meeting: English
🎟 Entrance donation: 10 eur
📍 Location: Maui coworking
(Note: For some reason, Meetup maps sometimes wrongly point to other addresses. Here is the exact address: [https://maps.app.goo.gl/fjx9t4zG8GnEmXLr9?g_st=ac](https://www.google.com/url?sa=E&q=https%3A%2F%2Fmaps.app.goo.gl%2Ffjx9t4zG8GnEmXLr9%3Fg_st%3Dac) )
Looking forward to a great discussion this Saturday!