If you can, check out the Sproutcore talk at the google technology user group tonight, 6pm @ google in Mountain View:
http://sv-gtug-11.eventbrite.com/(Yes, thats in 2 hours)
"With a new generation of high-powered browsers, like Chrome, it is possible to deliver native applications on the web that look and feel like the desktop. SproutCore is a new JavaScript framework that makes it easy to harness this power in your own software. It currently powers the desktop-like web applications at Apple's MobileMe service among many others."
I'll be there, and it'll be a great chance to meet other like-minded developers. And of course, the free food is always a plus.
-Michael Carter