What we're about

Brighton Café Scientifique is Science for the Sociable!

Informal talks of about 30-45 minutes are given by experts in the field, at a level accessible to all. After a break, the talk is followed by a question and answer session, and open discussion on the topic of the evening.

We meet on the second Wednesday of the month, at 7:30 for 8:00pm start at the Latest Music Bar, Manchester St, Brighton BN2 1TF. Meetings are free, although a collection is taken to contribute to the running expenses of the organisation.

Our dates for 2020: Wed 8 Jan, Tues 11 Feb, Wed 11 Mar, Wed 8 Apr, Wed 13 May, Wed 10 Jun, Wed 15 Jul, Wed 9 Sep, Wed 7 Oct, Wed 11 Nov, Wed 9 Dec (Note the Feb meeting is on a Tuesday)

Brighton Café Sci is part of the international Café Scientifique (http://www.cafescientifique.org) movement.

Please note: there are no regular meetings in August. Occasionally we may arrange meetings on days other than the second Wednesday of the month.

Upcoming events (1)

Red wine, chocolate, or...? The science of anti-ageing medicines.

***NB This event is now scheduled for December. No Cafe Sci event in April.*** Will red wine and chocolate really keep you healthy? The science behind the search for anti-ageing medicines, with Prof Lizzy Ostler on Wednesday 9th December - talk starts at 8:00pm. There is growing evidence that many of the processes of ageing, such as heart disease, dementia and arthritis, could be prevented or remediated by simple chemical compounds. Over the last five years, researchers have shown that the removal or alteration of the behaviour of senescent cells has the potential to reduce multiple age-related pathologies. The development of orally-available broad-spectrum anti-degenerative medicines based on targeting senescent cells is now a realistic goal. A wide variety of natural products, often isolated from “super-foods” including grapes and cocoa beans, have long been identified as potential lead compounds for such anti-ageing therapeutics. However, many such compounds have multiple biological activities, and may be poorly absorbed. We designed and synthesised a library of variants of Resveratrol, and have been using this panel of Resveralogues to find out how they really work, and whether they can be turned into real life anti-ageing therapies. A subset of our compounds is able to “rejuvenate” cultures of senescent cells. The implications of our findings for the design of future anti-degeneratives will be presented. Lizzy Ostler is Head of Chemistry in the School of Pharmacy and Biomolecular Sciences, University of Brighton. She took both her BSc in Chemistry and PhD in heterocyclic synthesis at Bristol University, before moving to Brighton to work on Catalytic Antibodies. There she was appointed lecturer in analytical chemistry and began to work closely with the ageing group. The application of analytical and synthetic chemistry tools to solve the problems of human ageing has been the focus of her research over the last 15 years, culminating in the award of a Professorial chair in 2018.

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