What we're about

This is a group for people interested in Synthetic Biology and open technologies: the DNA-based reprogramming and computational modelling of living systems and low-cost hardware for biological instrumentation. It is based in the University of Cambridge, supported by a strategic research initiative for interdisciplinary work in Synthetic Biology. The meetings provide a venue to explore new joint projects and there will be opportunities for funding. Register with the site to stay in touch and up to date.

For more information on the Synthetic Biology SRI go to http://www.synbio.cam.ac.uk

Upcoming events (5+)

See the Biomakespace - Introductory Tour

Biomakespace

Are you interested in getting involved in an interdisciplinary research project, meeting likeminded people, or finding out about engineering with biology? Come join researchers, scientists, engineers and technologists at the Cambridge Biomakespace. Located in the historic Laboratory of Molecular Biology near Addenbrooke's Hospital in Cambridge, the site has three lab spaces totalling just over 50sqm where it is possible to perform wetlab experiments and a workshop area for rapid prototyping, electronics and dry lab work. This tour is the first step to becoming a member of Biomakespace or just a great opportunity to have a look around and see more. Check out the website for more details: https://biomake.space/ Membership information can be found here: https://biomake.space/membership To find us: Ring the Biomakespace bell at the Clifford Albutt Building front entrance (up the steps to the left of the raised lecture theatre). The building is visible from the Addenbrooke's roundabout by the bus station.

Engineering Living Systems: From Genetic circuits to Microbial Communities

Our speaker Dr Somenath Bakshi is a new University Lecturer in Synthetic Biology. He is a single molecule biophysicist by training. Despite the rapid success of synthetic biology, synthetic circuits have been much less accurate and robust than natural ones, which has made it virtually impossible to connect synthetic modules into reliable networks. The stochastic nature of gene-expression, the unpredictable dynamics of the ‘unknown’ parts of intracellular genetic networks with which the circuit interacts, and the fluctuating environment in which cells live have made their operation fundamentally circumstantial. In order to design circuits that perform reliably, we are developing platforms that enable quantitative evaluation of the circuits in vivo with single-cell resolution and near-perfect control of growth-conditions, helping us to analyze and mitigate the effects of stochasticity, cellular interference, and environmental perturbation. We are also extending our interference assay to identify reliable elements, and design autonomous directed evolution platforms to engineer parts with improved functionalities in the native context. Another major goal of the lab is to replicate such approaches towards building robust and resilient synthetic microbial communities, which are cellular equivalents to genetic circuits, and relate to microbial networks in a similar way as the gene-circuits do to genetic network. Building such microbial circuits as motifs for microbial interaction network not only paves the way for understanding the modes of interaction in natural communities, but also to create novel functions that will surpass the limits of biotechnological potentials of individual microbes. ##About this Meetup Mondays at the Biomakespace are an opportunity to meet people, find out new things, share progress and ideas. We also meet on Thursdays, this is our work day for volunteers! If you'd be interested to help out, read the current openings for volunteers online: https://biomake.space/home/building-biomakespace/volunteering ##How to find the Biomakespace Postal Address: Biomakespace, Biomedical Innovation Hub [​Clifford Albutt Building], Biomedical Campus, Hills Road, Cambridge, CB2 0AH Finding us: We are located within the Biomedical Innovation Hub. Follow signs to the Clifford Albutt Building (see image), walk up the steps and ring the Biomakespace bell on our meeting nights. The bell is white with a blue button and a Biomakespace sticker, it will be by the 'normal' door on the right, not the circular doors.

Biomakespace Meetup

Biomakespace

Mondays at the Biomakespace are an opportunity to meet people, find out new things, share progress and ideas. We also meet on Thursdays, this is our work day for volunteers! If you'd be interested to help out, read the current openings for volunteers online: https://biomake.space/home/building-biomakespace/volunteering ##How to find the Biomakespace Postal Address: Biomakespace, Biomedical Innovation Hub [​Clifford Albutt Building], Biomedical Campus, Hills Road, Cambridge, CB2 0AH Finding us: We are located within the Biomedical Innovation Hub. Follow signs to the Clifford Albutt Building (see image), walk up the steps and ring the Biomakespace bell on our meeting nights. The bell is white with a blue button and a Biomakespace sticker, it will be by the 'normal' door on the right, not the circular doors.

Cell-free lunch with Dr Chiara Gandini (Bioeconomy Lab)

At the Bioeconomy Lab we are investigating and addressing fundamental issues in the access to biological reagents. In addition, we are developing research tools to make biotechnology accessible, used, and useful in resource-constraint contexts. Cell free protein synthesis (CFPS) will be explored as a proxy for in vivo protein expression of IP-free enzymes such as DNA polymerases, ligases and restriction enzymes. Genetic libraries will be cloned by LOOP-assembly and CFPS will be used as a high-throughput first-screening to select the most promising genetic combinations for protein expression. --- The SynBio SRI is pleased to announce a monthly lunch meeting series on cell-free synthetic biology, bringing together researchers and students leading or contributing to cell-free related projects. To join our mailing list for updates, training events and meetups, please visit www.tiny.cc/cellfree The meetings are intended to enable the latest technical advances in cell-free synthetic biology to be shared, grant opportunities and draft proposals to be discussed and better coordination of activities to take advantage of the substantial growth and opportunity we foresee in this area. It is also an opportunity to invite and involve experts in synthetic biology and sensing, knowledge transfer, technology implementation in resource poor environments and international development practitioners.

Photos (296)