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New Meetup: Tackling the "Undruggable" @ Broad Institute of MIT

From: T.J. M.
Sent on: Monday, June 15, 2009 11:47 AM
Announcing a new Meetup for Nerd Fun - Boston!

What: Tackling the "Undruggable" @ Broad Institute of MIT

When: July 22,[masked]:00 PM

Where: Click the link below to find out!

Meetup Description: Tackling the "Undruggable"
Wed, July 22nd, 6-7pm
Angela Koehler, Ph.D.
"There are hundreds of thousands of proteins in our bodies, many of them with links to human disease. But only a tiny fraction of these proteins is considered 'druggable' -- that is, able to be targeted by drugs. Thanks to a new generation of drug discovery technologies, that tiny fraction is now on the rise. Angela Koehler will describe one of these new technologies and how it can be used to identify potential drugs that do the impossible: bind to and disrupt the functions of 'undruggable' proteins' ".

About Angela Koehler:

"Angela Koehler is a group leader in the Broad Institute?s Chemical Biology Program. Angela?s research program aims to identify functional small-molecule probes of disease-relevant transcriptional regulators that may be developed into imaging agents, diagnostic tools, or therapeutic leads.

"Angela?s group uses small-molecule microarrays (SMMs) and surface plasmon resonance to discover and characterize interactions involving various proteins and small molecules coming from natural or synthetic sources. SMMs allow rapid screening of structurally diverse compounds against nearly any protein target that can be expressed and purified or detected directly from cell lysates. She has developed microarrays that contain known bioactive compounds, FDA-approved drugs, natural products, and compounds prepared through diversity-oriented synthesis. While her group screens SMMs to find ligands for a variety of proteins involved in cancer pathways (e.g., Aurora A, JAK2, p110β), their efforts are heavily focused on ligand discovery aimed at transcription factors and other transcriptional regulators such as histone deacetylases. Traditionally, transcription factors have been considered undruggable in part because the design of small molecules that disrupt protein-protein or protein-DNA interactions is a challenge. Her group has screened more than 100 human transcription factors against SMMs to date and has identified functional small molecule ligands for various transcription factors including NF-YB, NF-κB, and TFIID".

Where to Meet:
Getting off at Kendall Square, walk down Main Street past Legal Seafoods, and cross Ames street. The Broad Institute is on the right. T.J. Maher will be waiting outside the lobby entrance near the large sign. T.J. Maher is 5 foot 7, with short hair, blue eyes, a "Hello My Name is T.J." nametag, and a red MEETUP sign attached to his black messenger bag.

Instructions how to Register:
Just check off the days of the lecture you wish to go to.

About Midsummer Night's Science:

"Midsummer Nights? Science will recount the scientific transformation that began more than a century ago with the seminal studies by the Austrian monk Gregor Mendel ? the ?father of genetics? ? who observed the ways in which physical traits were passed from one pea plant to another. In honor of the scientific field it helped to launch, the pea plant provides the inspiration for the seminar series, which takes its name from one of William Shakespeare?s well-known plays.

"Midsummer Nights' Science at the Broad Institute takes place at 7 Cambridge Center, Cambridge. The series will run on Wednesday evenings on July 8th, 15th, 22nd and 29th from 6 ? 7 o'clock. Lectures are free and open to the public".


Learn more here:

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