JavaScript Admirers' Monthly Meeting

In a world where any word you can think of is probably the name of a JavaScript framework, library, or other random tool (Cycle? Omniscient? Taffy!? Ember?), what is the state of JavaScript WITHOUT a framework? Here in 2019, JS has come pretty far, after all. How hard would it be to make a single-page app with just JS?
David Zulaica dares to ask the question: "Are frameworks necessary in 2019?" What's possible now...and what's not?

We JS Admirers love code so much, we even have a Code of Conduct: http://pdxjs.com/code-of-conduct/