What we’re about
The club is an informal group at Moffitt dedicated to promoting a fun and supportive culture for learning biological data science. Our meetings are intended for all levels of computational backgrounds. We meet once a month in one of the Moffitt research buildings on the USF campus. The public is encouraged to attend! More information is available at www.biodataclub.org .
Upcoming events
1
•OnlineShinyEvents: A Tool to Harmonize Longitudinal Data
OnlineLongitudinal data analysis of the patient’s treatment course is critical to uncovering variables that influence outcomes. However, existing tools have significant limitations in integrating multilayered time-series data, particularly in linking treatment events with survival outcomes. Here, we developed ShinyEvents, a web-based framework for complex longitudinal data analysis. ShinyEvents allows users to upload data and generate interactive timelines of clinical events, enabling cohort-level analyses such as treatment clustering and endpoint assignment. It also provides informative cohort visualizations, such as a Sankey diagram of the treatment line and a Swimmer diagram of the clinical course. Finally, our tool can infer real-world progression-free survival (rwPFS) based on user-defined endpoints and perform Kaplan-Meier and Cox proportional hazards regression analysis. With these features, the tool can then associate treatment lines with clinical outcomes. As a case study, we analyzed Moffitt patients with muscle-invasive bladder cancer treated with neoadjuvant chemotherapy followed by surgery. Patients treated with cisplatin and gemcitabine exhibited more favorable rwPFS and overall survival, which is consistent with prior reports. Altogether, ShinyEvents provides a unified framework for integrating longitudinal real-world data with survival analytics, fostering transparent and reproducible collaboration between clinicians and data scientists. A live demo is available at https://shawlab-moffitt.shinyapps.io/shinyevents/.
1 attendee
Past events
30
