How and when to give up on people

https://youtube.com/shorts/DnKQ7Wc9A0w?si=0tPIi86mfTHZGZRb

How and when should you give up on someone?

Most of us think of ourselves as "good people", and good people dont give up on someone they care about?

What are the signs that suggest you should?
Is it situation-specific, or when should we give up the relationship entirely?

If and when have you encountered this, and with what results?

To what extent should you be pro-active, vs just passively leaving the person or situation?

Do you want to give it one more try, or is it just "beating a dead horse"?