Integrating gene expression and DNA-binding data using R/Bioconductor

We are delighted to get back to the R4Bioinfo series that we've launched in September 2020. We will be organizing a new workshop which will serve as an overview of the integrating gene expression and DNA-binding data using R/Bioconductor.

Date/Time : Saturday, February 27, 2021 from 2 PM to 4:15 PM (GMT+1)
Place : Zoom https://zoom.us/download

▶️ Invited trainer : Dr. Mahmoud Shaaban
▶️ About Dr. Mahmoud Shaaban :
Dr. Mahmoud Shaaban graduated from medical school, Cairo University, Egypt, in 2015. He received his master's and PhD from Gyeongsang National University, Korea, in 2021, where he studied the role of autophagy in development and disease. He used R/Bioconductor to analyze gene expression and transcription data from mice models. He wrote open-source R packages to distribute the data, methods, and code of my research

Description of the workshop :
Researchers use ChIP binding data to identify potential transcription factor binding sites. They use gene expression data from sequencing or microarrays to quantify the effect of the factor over-expression or knockdown on its targets. The integration of the binding and expression data therefore can be used to improve the understanding of a transcription factor function. In this workshop, I present a complete workflow for integrating the gene expression (microarray/RNA-seq) and DNA-binding data (ChIP-seq) to predict the combined function of two transcription factors using R/Bioconductor. The example we will be using in the workshop is from real datasets of two functionally and evolutionary related transcription factors YY1 and YY2 in HeLa cells. We will try to identify the factor-specific and the shared targets of the factors in this particular cell line. Then we will use a technique find out the aggregate functions of the factors on their individual (inducer or repressor) and common targets (cooperative or competitive).

More details about the workshop are provided through this link https://mahshaaban.github.io/IntegratingDataBioc/

In order to attend the event, please fill out this form 👉 https://tinyurl.com/y7kzasq7

We will send you the Zoom link and the enter passcode a few hours before the training session. Please check out your email later.

Don't forget to add the workshop to your calendar so that you can get a reminder about it.

We look forward to welcoming you!

If you have any questions, please don't hesitate to contact us ⬇️

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