BioInformatics

The personal communication and dating world is evolving rapidly. We’re moving from exhausting repetitive small talk to sophisticated personal AI agents and digital alter-egos. It’s time to sync up and discuss how to build, evaluate, and scale an open-source "second brain" for authentic human connection. ​Join us for a deep dive into personal knowledge graphs, agentic memory, and hands-on experiences in building your digital twin. We will discuss how to apply recent suggestions by Andrey Karpaty https://www.mindstudio.ai/blog/andrej-karpathy-llm-wiki-obsidian-ai-second-brain to dating and mactchmaking in agentic style. ​Key Topics: ​**Personal Knowledge Bases & Agentic Memory:** Practical patterns for moving beyond basic RAG (like NotebookLM) to robust, updateable memory systems (Supabase, MCP) to handle fact deduplication, source tracking, and hallucination reduction. ​**The "How Would I Answer?" Engine:** Crafting precise instructions and tone-of-voice guidelines so your agent can extract factual history and draft sincere, engaging responses that truly reflect who you are. ​**Multi-Agent Verification Pipelines:** Using parallel LLM evaluations to independently score generated messages. Measuring what matters: "How naturally does this read?" and "Does this align with the goal of being sincere and attractive?" ​**Digital Alter-Egos & Agent Matchmaking:** Exploring the future of compatibility—from giving agents the ability to "sniff each other out" for goal alignment, to the ultimate objective of using AI to make us calmer, more present, and less reliant on screens. ​Open Discussion: Bring your own use cases, failures, and breakthroughs. Whether it's extracting facts from thousands of personal chat logs without losing context, managing fragmented LLM memories, or building the perfect verification harness for your digital twin — let’s figure it out together. Langauge: english with some russian and spanis conversations probably

Amateur Actors Barcelona is a weekly acting class, for anyone interested in getting acting experience. We review scripts from popular films, watch the footage on a projector, then act the scenes out on stage. One hour of acting, followed by networking with other actors at a local bar. Join us Monday and Wednesday evenings in Barcelona. Tickets are €10.00 - via Bizum. No cash payments at the entrance. This week we will be focusing on: "No country for Old Men" - https://youtu.be/38A__WT3-o0?si=u9WgN-oYPcyLIcQw "Carnage (2011)" - https://youtu.be/RhVRcSbX53I?si=tNI6ZLDJS0NklpQt See you there!

Buzoku Meetup | Web3 and AI | Barcelona Join us in Sant Gervasi for Buzoku, a bi monthly casual meetup for people building in Web3, AI, and digital systems. What started as a Web3 focused group is now expanding to include AI builders as well. The format No panels No presentations No agenda We meet at a bar, grab a drink, and talk. That is it. Who comes A mix of: • Engineers and technical builders • Founders and operators • Investors and traders • Designers and curious minds Working across: • Crypto, Web3, and digital assets • AI, agents, and applied machine learning You do not need to be working at the intersection. If you are deep in either space, you will find your people here. We are also very interested in where AI and crypto meet, including agentic systems, automated finance, and new coordination models. What to expect • Real conversations about what people are actually building • War stories, ideas, experiments, and lessons learned • A relaxed environment where you can meet people naturally No pressure to pitch. No structured talks. Just good people and good discussions. Why join • Meet high quality builders in Barcelona • Exchange ideas without the noise of formal events • Find collaborators, hires, or new opportunities 🍺 🍷 Drinks on us, both alcoholic and non alcoholic We try to keep the group high signal. If you are actively building or deeply involved in AI or crypto, you will get the most out of it.

**⚠️ [Register on the official site of the event](https://www.lewagon.com/events/open-house-at-le-wagon-barcelona-buuZn4)** Thinking about switching careers or levelling up your tech skills? Come see us at Le Wagon Barcelona on **Wednesday, 3 June.** Our doors are open from **11am to 6pm**, so stop by whenever suits you best. **Register for our Open House** and explore at your own pace. No agenda, no presentations. Just walk in, explore the space, and talk to the team to learn more about Le Wagon. **What's waiting for you:** * 🏫 **Campus tour**: check out our space and get a feel for what it's like here * 🤝 **Meet the team**: talk to our teachers, staff and students * 📚 **Course details**: figure out which bootcamp works for you * 💸 **Funding**: find out what's on offer (payment plans, ISA, scholarships) 🗓 Wednesday, 3 June - bwtween 11am and 6pm 📍 Carrer de la Diputació, 409 Barcelona ✅ Register to save your spot **⚠️ [Register on the official site of the event](https://www.lewagon.com/events/open-house-at-le-wagon-barcelona-buuZn4)**

Muchas personas quieren emprender, pero no quieren empezar de cero ni hacerlo solas. En esta charla compartiré un modelo de negocio actual basado en las conexiones, enfocado en personas con mentalidad emprendedora y/o perfil comercial que quieran explorar una alternativa profesional real. \- Para quién es: * Personas que quieren desarrollar un negocio propio * Comerciales o personas a las que les gusta vender * Gente abierta a nuevas formas de generar ingresos \- Qué encontrarás: * Visión clara de un modelo de negocio actual * Espacio para preguntas y criterio propio * Networking con personas afines No es una oferta de empleo tradicional. Plazas limitadas.

L'intercanvi lingüístic es inglès/català-castellà. Els horaris son de 11h à 13h. El cost per sesió es de 4 Euros.

**(CASTELLANO a continuación** 📷 **ENGLISH below)** **Què dir de Siurana? Doncs que és un d'aquells llocs on les paraules es queden curtes per descriure la seva màgia!** Així que tocarà viure-ho! Començarem el dia esmorzant en **un dels miradors més espectaculars de Catalunya, amb vistes privilegiades sobre la cinglera i el pantà, que després de molts anys, torna a estar ple!!!** Tot seguit, passejarem pels carrers del poble, un dels més pintorescos del Priorat, mentre descobrim la seva història i contemplem l’**impressionant Salt de la Reina Mora, on reviurem la llegenda que dóna ànima a aquest indret**. A continuació, iniciarem una **ruta circular d’uns 13km i 450m de desnivell, que ens portarà a baixar cap a la vall per endinsar-nos en un entorn natural sorprenent**. Resseguirem el riu dels Gorgs, un racó fresc i salvatge amb tolls d’aigua cristal·lina, ideals per descansar… i, si ve de gust, refrescar-nos! 💦 **Ens espera un dia inoblidable combinant paisatge, història i natura en estat pur. T'hi animes? ;-)** ℹ️ **Detalls pràctics:** * **Preu:** 25 € excursió + 15 € cotxe (es paga directament al conductor/a) = **Total: 40€** * **Inclou:** guiatge per guia titulat, assegurança d'accidents + responsabilitat civil. * **Targeta Nature Connect:** cada 10 rutes... **1 gratuïta!** 🥪 Què cal portar? * Picnic per dinar en ruta * Mínim 1,5 L d’aigua * Calçat de muntanya i roba en capes (adaptable al temps) * banyador i tovalloleta * Bastons opcionals ❗️ Política de cancel·lació: * ✅ Fins a **48 h abans**: devolució del pagament (amb descompte de 5 € per gestió) o **canvi per una altra ruta** dins dels pròxims 6 mesos. * ❌ Passades les 48 h: **no es faran devolucions ni canvis**. Gràcies per la teva comprensió! 📲 Segueix-nos i estigues al dia! * 📷 Al nostre Insta 👉 [Instagram](https://www.instagram.com/natureconnectbarcelona) * 😎 a Can Facebook 👉 [Facebook](https://www.facebook.com/natureconnecthikes) * 🥰 **i uneix-te al 👉 [Grup de WhatsApp](https://chat.whatsapp.com/H8fQ4srpGthI7j1OWyuBYQ) 👈** per estar informat de properes sortides! Per a + INFO, no dubtis a contactar-me (preferiblement via **WhatsApp**) ☎️ **609 309 797 (Jordi)** \-\-\-\-\-\-\- 🌼 **CASTELLANO 📷** **¿Qué decir de Siurana? Pues que las palabras se quedan cortas para describir este lugar único! Así que tocará vivirlo!** Empezaremos el día desayunando en uno de los miradores más espectaculares de Cataluña, con vistas privilegiadas sobre el acantilado y el embalse, que después de muchos años vuelve a estar lleno! A continuación, pasearemos por las calles del pueblo, uno de los más pintorescos del Priorat, mientras descubrimos su historia y contemplamos el impresionante Salto de la Reina Mora, donde reviviremos la leyenda que da alma a este lugar. Seguidamente, iniciaremos una **ruta circular de unos 13km y 450m** de desnivel, que nos llevará a descender hacia el valle para adentrarnos en un entorno natural sorprendente. Seguiremos el curso del río de los Gorgs, un rincón fresco y salvaje con pozas de agua cristalina, ideales para descansar… y, si apetece, refrescarse. **Una experiencia completa que combina paisaje, historia y naturaleza en estado puro... ✨ ¡no te la pierdas!** ℹ️ **Detalles prácticos:** * **Precio:** 25 € excursión + 15€ coche (se paga directamente al conductor/a) = **Total: 40€** * **Incluye:** guía titulado, seguro de accidentes + responsabilidad civil. * **Tarjeta Nature Connect:** cada 10 rutas… ¡1 gratis! 🥪 **¿Qué hay que llevar?** * Picnic para comer en ruta * Mínimo 1,5 L de agua * Calzado de montaña * Ropa por capas (para adaptarnos al clima) * Bastones (opcionales) ❗️ **Política de cancelación:** * ✅ Hasta 48 h antes: devolución del pago (menos 5 € de gestión) o cambio por otra ruta dentro de los próximos 6 meses. * ❌ Pasadas las 48 h: no se realizan devoluciones ni cambios. ¡Gracias por tu comprensión! 📲 **Síguenos y mantente al día:** * 📷 En Instagram 👉 [Instagram](https://www.instagram.com/natureconnectbarcelona) * 😎 En Facebook 👉 [Facebook](https://www.facebook.com/natureconnecthikes) * 🥰 Y únete al **👉 [Grupo de WhatsApp](https://chat.whatsapp.com/GnAyY0TPC259jA8FC2jIJy) 👈** para estar al día de nuestras próximas salidas **Para + INFO, no dudes en contactarme** (preferiblemente por WhatsApp) ☎️ **609 309 797 (Jordi)** \-\-\-\-\-\-\- 🏞️ **ENGLISH** 🦗 **Siurana. What can be said about this place? Words truly fall short to describe this unique spot in the world, so it’s better to experience it!** We’ll start the day with breakfast at one of the most spectacular viewpoints in Catalonia, enjoying privileged views over the cliffs and the reservoir, which has finally filled again after many years. Then, we’ll stroll through the village streets—one of the most charming in the Priorat region—while discovering its history and taking in the dramatic Queen’s Leap, where we’ll revisit the legend that gives this place its soul. Afterwards, we’ll begin **a circular hike of around 13km with 450m** of elevation gain, descending into the valley and entering a truly remarkable natural setting. Along the way, we’ll enjoy refreshing spots and wild landscapes, perfect for resting and admiring nature. **A truly unforgettable day blending landscape, history, and nature at its finest. Don't miss it out!** ℹ️ **Practical info:** * **Price:** €25 for the hike + €15 for car transport (paid directly to the driver) = **Total: €40** * **Includes:** certified guide + accident and liability insurance * **Nature Connect Card:** every 10 hikes… 1 free! 🥪 **What to bring:** * Picnic lunch * At least 1.5 L of water * Hiking shoes & layered clothing (weather can change!) * bathing suit & towel * Trekking poles (optional) ❗️ **Cancellation policy:** * ✅ Up to 48 h before: refund (minus €5 admin fee) or a transfer to another hike within the next 6 months. * ❌ Less than 48 h before: no refunds or changes. Thanks for your understanding! 📲 **Stay connected:** * 📷 On Instagram 👉 [Instagram](https://www.instagram.com/natureconnectbarcelona) * 😎 On Facebook 👉 [Facebook](https://www.facebook.com/natureconnecthikes) * 🥰 Join our **👉 [WhatsApp group](https://chat.whatsapp.com/GnAyY0TPC259jA8FC2jIJy) 👈** to stay updated on upcoming outings **For more info, feel free to contact me** (preferably via WhatsApp) ☎️ **+34 609 309 797 (Jordi)**

**Latest Dojo Location!** **Knotty Pine Brewing** 1765 W 3rd Ave, Columbus, OH 43212 We're going to try a new dojo location for a few weeks and see how it works Dojos are informal Python group study sessions where everyone interested in Python gathers to learn about Python, help others with Python, or just hang out. Everyone is welcome from Python beginners to experts. Bringing a laptop is encouraged (we'll have extension cords and power strips). If there's something you want to learn leave a comment on this invite so we can plan ahead. We're looking for speakers for our Monthly Meetups! Fill out the form if you are interested in presenting to the Python Community. https://forms.gle/ehSfUAC2WgR34Crq9

Topic to be announced. **THANK YOU** *Franklin University* for hosting our meetup! To learn more about *Franklin University*, please visit their website: https://www.franklin.edu/ **DIRECTIONS** Franklin University Fisher Hall 300 E. Main St, Columbus, OH 43215 Map: https://maps.app.goo.gl/jxjBA2hUmS5qrvhq8 Parking is FREE! Please park in Lot C in front of Fisher Hall. See attached map. NOTE: Map the address only. When mapping with Google Maps it may use the Fisher Hall at OSU, which is NOT correct. **Want to sponsor the pizza and/or bar tab?** Please contact me if you would like to sponsor this meetup's pizza and/or bar tab: angelo@mandato.com

Want to be a speaker? submit your talk to our Call for Presenters!!! https://sessionize.com/azure-cbus-2026/

**Join Katie McCartney, SRES®, for a clear and easy‑to‑understand update on what the 2026 Central Ohio housing market means for seniors and their families.** Whether you’re planning ahead, helping a parent make decisions, or simply trying to understand today’s market, this session offers reliable insights without pressure or overwhelm. During this free class, Katie will break down the trends shaping housing for older adults in Central Ohio, explain what families should realistically expect in 2026, and answer your questions during an open Q&A. This is a supportive, information‑focused workshop designed to give you confidence and clarity — no sales pitch, just helpful guidance. *** **Ideal for:** * Seniors considering future housing options * Adult children supporting aging parents * Anyone seeking a calm, trustworthy source of market information *** **What You’ll Learn:** * A senior‑friendly look at the 2026 Central Ohio housing market * Personalized answers during an open Q&A You’ll leave with a better understanding of your options and your next steps. *** **Hosted by:** **Katie McCartney, Broker & Senior Real Estate Specialist® (SRES) with** Pillar Realty, LLC Compassionate guidance for seniors navigating housing transitions in Central Ohio. *** **Location:** Columbus Metropolitan Library: Dublin Branch 75 N High St, Dublin, OH 43017 ([https://maps.app.goo.gl/GL2vbJgUHqTncbHZ9](https://maps.app.goo.gl/GL2vbJgUHqTncbHZ9)) Meeting Room 3 **Doors Open:** 1 PM **Seats:** Limited Seating (first come, first served) **Cost:** Complimentary

QA or the Highway is a one-day, affordable, regional, professional conference featuring real-world experience and thought leadership in the QA and testing industry. This is a ticketed event please register here: https://www.qaorthehwy.com/ Featured Keynote Speakers: **Matthew-Hope Eland** **(Wizard at Leading EDJE)** \- An AI Specialist and Wizard at Leading EDJE who is known to teach software engineering\, AI\, and data science concepts in the most ridiculous ways possible\. Matt has used machine learning to settle debates over whether Die Hard is a Christmas movie\, reinforcement learning to drive the behavior of digital squirrels\, data analytics to suggest improvements to his favorite TV show\, and AI agents to play board games and create an AI agent with the personality of a dog\. Matt is the author of "Data Science in \.NET with Polyglot Notebooks" and "Refactoring with C\#" as well as several LinkedIn Learning courses\. Matt helps organize the Central Ohio \.NET Developer Group\, runs several blogs and a YouTube channel\, has a Master’s of Science in Data Analytics\, and is a current Microsoft MVP in AI and \.NET\. **Tatyana Arbouzova** **(CEO at Innovate QA)** \- Tatyana Arbouzova is an engineering and business leader with a strong background in Quality Engineering across multiple industries\, including Big Tech\, Healthcare\, and Entertainment\. She has held leadership roles at world\-class companies such as Microsoft\, VMware\, Disney\, and The Pokémon Company International\, where she focused on building quality\-driven cultures and scaling teams to deliver high\-impact products\. With decades of experience\, Tatyana has helped organizations transform their quality practices so teams can deliver software efficiently\, confidently\, and with measurable business outcomes\. Today\, Tatyana advises software companies on adopting AI to optimize quality practices and improve how software is delivered at scale\. She is also a passionate community builder and the founder of Innovate QA\, a thriving Seattle\-based community and conference for quality professionals\.

June 17, 2026: Worthington Library. Wild Ohio: The Best of Our Natural Heritage. Jim McCormac. Worthington, Ohio. 7 pm.

We have moved to guild.host. Look us up there. https://guild.host/events/buckeye-cocoaheads-rcavwd