Cancer

Title: What Is Progress? Knowledge Aggregation, Living Textbooks, and the Automation of Scientific Discovery Date: June 20 2026 Noon - 14:00 EDT Summary: Our collective knowledge infrastructure — the textbooks, professional training resources, and literature syntheses that define what professionals across disciplines believe to be true — is quietly accruing a structural liability. Compounded confirmation bias, stacked citation-by-citation into the foundations of formal knowledge, means that breakthroughs can take decades to reach the classrooms, clinical workflows, and decision-making frameworks where they matter most. Meanwhile, the deepest friction is rarely acknowledged: before any field can build meaningful consensus on "why" or "how" a phenomenon occurs, it must first establish honest, consolidated agreement on "what" has actually been observed. That prior step is routinely skipped, assumed, or fragmented across siloed literatures that never cross-pollinate. This talk introduces a framework called "Knowledge Aggregation" — with two distinct but complementary ambitions. The first is descriptive transparency: algorithmically mapping what has been said, measured, and documented across a problem space, without imposing causal interpretation or narrative. The second traces the boundary between empirical observation and explanatory claim, building systems that can separate the "what" from the "why/how" — because consensus on mechanism cannot be meaningfully constructed until consensus on phenomenon is first established. Both ambitions are now within reach. By composing tools already at our disposal — large language models, classical NLP pipelines, public data repositories, and engineering-grade automation frameworks — it becomes possible to model knowledge itself, rather than merely imitate individual experts. One concrete expression of this is automating the writing of living textbooks: compressing the lag from bleeding-edge discovery, through replicated evidence, all the way to professional training resources. But the deeper aspiration reaches further — toward automating the discovery of scientific insights that have never previously been conceived, by systematically surfacing hypothesis combinations that no single siloed researcher would have had the cross-disciplinary vantage point to even ask. Drawing on ongoing systems biology and computational research — with ME/CFS research demoed as a use case for what siloed, fragmented knowledge infrastructure costs in practice — this talk maps the conceptual architecture, the real-world friction, and the data science toolkit for building it. Speaker: As a systems biologist at heart, Sam specializes his biomedical research on interactions and connections in biology - rather than just one domain of expertise. He wears many hats and collects skill sets across disciplines, with degree studies and industry experience acquired across Chemical Engineering (BSc), Bioinformatics (MSc), Systems and Synthetic Biology (M2), Biomedical Sciences (MSc), and beyond. Even more important to him than niches or fields of work, comes down to the synergistic approaches that allow us to move beyond reductionism. The notion that a question can only allow for one answer, is inherently reductionist. By resisting many norms in science and engineering which can get overly reductive, his current role as Principal Investigator of Research for DMV Petri Dish (501(c)(3) non-profit local to the DMV region) embraces computational frameworks that aide scale-up and automation - not only around the processes which already exist with established workflows, but also taking a keen interest in attempting and accomplishing ambitions which have never been perceived to be possible previously. Sam carries a passion for the synergy of computational biology - fused with wet lab validation. This way, one can build a beautiful knowledge base in the theoretical sense, and then test to see if said computational prediction might actually be able to stand in the real world with wet lab validation. Translational modeling starts to become possible once biological experiment design can be iteratively looped alongside computational model design, optimization, and analysis - empowering the design of a better wet lab experiment, followed by a better computational model, back and forth until science is done!

[Book Your Classes by Clicking This Link! ](https://crowndancestudio.com/group-classes/) Start your weekend with elegance and poise during our **Beginner’s Ballroom sessions at 10:30 AM and 11:15 AM**. These classes provide a welcoming, family-friendly environment where students of all ages can learn the fundamental steps of classic dances like the Tango and Rumba. Focusing on grace, posture, and the joy of movement, these sessions are **priced at $18 per class,** offering an accessible way to master the "American Smooth" styles in a relaxed morning setting. 10:30 1 American Smooth Dance. 11:15 I American Rhythm Dance. Cost: $18 for 1 Class. $25 for 2 Classes.

### Hopeful Cafe Conversations @Panera Kentlands **You are cordially invited to join in the conversation to catch the positive vibe... a cup of coffee, or another of your favorite refreshment.** **At NEW HOPE CAFE CONVERSATIONS on 3rd Saturdays, Monthly** **Address: Panera, 285 Kentlands Blvd., Gaithersburg, MD 20878** **Zoom Link: https://us06web.zoom.us/j/83326239362** ===== **New Hope Workshop**: What is Negativity Bias? How do we get ahead of it to reach more positive outcomes in work, life, and relationships? Discover the difference between goals and outcomes. 1\. How do we reaffirm ones role\, despite negativity bias from others? 2\. The New Hope Community Affirmative Statements of Foundational Principles 3\. Your Perspectives in Conversation **"Star Points Meal Deal"** If you have New Hope "Star Points 💫" you can get a discount on a meal. Also you can earn Star Points, if this is your first time attending Cafe Conversations, in-person. Ask Gene, newhope321community@yahoo.com, 240-848-0808.

● Ultra-light ball (\~1/8th as heavy as a normal 5). This allows zero chances of ball causing brain injury. (Hence the name, Soccer Zero.) It's also nice to do toe kicks! ● Injury-based foul system. This means that the rules apply even for same-team-side fouls, too. You can use your hands to protect yourself from the ball; hand balls are only called if you did it to gain an advantage. Yellow cards will cause the fouler to sit out for 120 seconds. Strong kicks of balls to anyone's head, called "face kicks", or nuts (for male players only), are yellow-card fouls even though the ball is so light it doesn't matter as much. This penalizes inconsiderate play, something we really do care about. Reckless players or anyone getting a red card is banned. (Before heading, you need to have an idea of where other nearby players are.) So, as an example, if you kicked the ball at high speed to your own teammate's head you still have to sit out for 2 minutes. ● No out of bounds. This makes it more interesting and easier to ref. ● No offsides. ● No goalies for the senior team. (The senior team is the one that is ahead in points.) This rule is used in place of an offsides rule, since it implies you cannot win by sticking some fat player who stands in front of their relatively small Pugg goal all day long. We define a goalie to be any defender intentionally within the "goal area". In turn, this *goal area* is defined as the ground in front of the goal covered by the top of the goal, were the goal to be tipped forwards onto the ground, similar to what would happen if the wind blew strongly from behind and the stakes were not secured. ● Goal resizing. Sometimes a strong player comes on mid-game after teams were picked by the two captains. If someone like Ronaldo joins a team and/or both captains agree to goal resizing to make the game more balanced the game will be stopped and the goal sizes altered to make it more even. Please don't suggest team shuffling as a better method. It destroys the team spirit. If the switched player sucks, it will add insult to injury to him or her. On the other hand, if the switched player is good, past points stack against him or her, which also destroys the game integrity, much of which is about trying to get your team to win. Goal resizing and point multiplying (each point counts as 2 for the junior team) maintains game integrity and helps maintain balance and game intensity. Games are in Silver Spring, MD. They are reffed. Clean red and blue pinnies are supplied when needed. A weekly invitation including a recap of the prior week's game is sent out to any players who want to read it. See here (https://www.meetup.com/safersoccer/boards/thread/23643732/0/). RSVPs are required. The reason is that it should increase their own enjoyment. You see, the ideal number of players for a pickup soccer game is perhaps 6x6 - 8x8; some players won't attend if they think the turnout will be low, and others will just assume the game will be cancelled even though we always play. (As a practical matter, smaller games are less fun since the comics won't have the audience they need, but, they do have two hidden benefits: shorter, more intense games/workouts and fewer face kicks/yellow cards. So we play no matter how small or large.) So non-RSVPers are a little short sighted, since they don't seem to want to maximize their own enjoyment in the long run. Rational and sane players who have a good chance of attending RSVP a week early here [and in the subgroup](https://www.meetup.com/safersoccer/). Location map (cut & paste url into a browser)(park on Plyers Mill): secure.meetupstatic.com/photos/event/2/1/7/2/600_364808562.jpeg

We'll check out 29th Parallel Coffee in Fairfax Station. We plan to grab a coffee and head to Burke Lake Park and walk around the lake (weather permitting). There are a couple of parking areas at the park. I marked the parking we're planning to meet at the park. We hope to start the walk around 11:30AM. If you're a Fairfax County resident (with an ID), parking is free, otherwise they charge for parking. Please have a picture profile so we can recognize you in the meetup.

Hey Poetry Lovers! This group is on a roll. Here’s the gist: We meet at the **Capital One Café in Chinatown** from **12pm - 2pm** every other week. For enrichment, we start by reading and reflecting on a **“published poem”**, suggested by someone in the group. No advance preparation is necessary. But feel free to check out some of the poems we’ve read [here](https://docs.google.com/spreadsheets/d/e/2PACX-1vSyE_wCLQCPHRrKmN5F9tOIeeRQUZESxjRXGVBoCF2uU8Gm0_d0uECiCBCQXEy6ksxfsBOhtRIOpW3T/pubhtml?gid=0&single=true&widget=true&headers=false%22%3E%3C/iframe%3E). Or submit suggestions for future meetings [here](https://docs.google.com/forms/d/e/1FAIpQLSexGc2Z2Kp6bZW0D3_hfJ7NUUkfNHf7TXX-43FglCeBd9EF2Q/viewform?usp=send_form). Next, we **share our work and offer feedback**. Depending on attendance, everyone gets \~10 minutes to use as they like. (No need to share, though; you’re welcome to come even if you prefer just to listen.) We maintain a **Discord server** to help share our work and communicate outside our bi-weekly meet-ups. If you haven’t used Discord before, take a moment to download it and create an account before arriving. When we meet you on Saturday, we will add you to our server, the “DC Poetry Workshop”, and can help you navigate the app if you have questions. Finally, if you plan on sharing a poem, consider how you will do so. Some options include: * Print 5-10 copies to distribute in person * Take and share screenshots in the Discord chat. * Copy the poem into a google doc, change sharing settings to “anyone with link”, and copy the google doc link into the Discord chat. Most importantly, we’re excited to meet you! Catch you on Saturday, Diego / Ian / Cayden / Nate / Otasha / Lia / An

We are NPS Weed Warriors and Arlington Regional Master Naturalists and you should volunteer with us on Sunday, May 17 to learn about nature and remove invasive plants from everyone's favorite urban island. Meet us at the entrance to the bridge (on the parking lot side, look for the sign) at 10:00 and bring your garden gloves and loppers/pruners if you have them. If not, we can provide gloves and tools. Wear long sleeves and pants and don't forget a water bottle. We will have tasks ranging from easy (cutting English ivy and honeysuckle vines from trees) to hard (sawing down bush honeysuckle). Parking at TRI can be tight if it's a pretty day. When the parking lot is full, you can park in Rosslyn and take the trail down. If you can bike or walk or take public transit, that's wonderful. We'll see you there! Erica, Stephanie, and Heidi P.S. If you can't wait until then to RIP (Remove Invasive Plants!), go here to find more volunteer opportunities in Arlington parks: [Volunteer to Restore Native Habitat – Arlington Regional Master Naturalists (armn.org)](https://armn.org/volunteer-opportunities/)

This is an absolute beginner Salsa group class. It is specifically designed for those with no prior experience in Salsa and participations does not require having a partner. Every Other Sunday: $25 per person. [Click Here to Sign Up](https://crowndancestudio.com/) 2:00 pm to 3:30 pm Beginner Bachata.

Ultimate 80's Rock band and post-event karaoke at Mark's Pub. Get dressed up in 80's attire. Here's ticket link: The Legwarmers: The Ultimate 80's Retro Dance Party Tickets - The State Theatre - Falls Church, VA - Saturday, June 20, 2026 — 9:00 pm https://share.google/HwAQpSAzJA7JcpqUG

Join us in celebrating International Yoga Day with a special talk by author Mark Mays. In this engaging session, Mark Mays will guide a live meditation and share his personal journey of self-realization, along with insights from his book Tell the World: An Author’s Journey of Meditation and Inner Transformation, offering a deeper understanding of inner peace and self-awareness through Sahaja Yoga. All attendees will receive complimentary entry along with a free PDF copy of the book. The session will be followed by light refreshments and an opportunity to connect with others. Walk-ins are welcome.

Sleep, Rest & Connection: Building Our Community Together Join us for the next gathering of The Pause Collective — a supportive meetup for neurodivergent women navigating perimenopause, menopause, burnout, overwhelm, and life transitions. Since many of us haven't yet had the opportunity to meet, we'll begin by getting to know one another and sharing what brought us to this community. We'll also explore one of the most common challenges many women experience during this season of life: sleep. Whether you're navigating insomnia, waking up in the middle of the night, racing thoughts, night sweats, exhaustion, burnout, or simply not feeling rested, you're not alone. This will be a relaxed, low-pressure coffee shop meetup focused on connection and conversation. No need to prepare anything. No pressure to share. Come as you are. Together we'll: • Introduce ourselves and get to know one another • Share what brought us to The Pause Collective • Discuss sleep, rest, and energy during perimenopause and menopause • Exchange ideas, experiences, and support • Explore what topics we'd like to discuss in future gatherings • Continue building the kind of community we'd like to create together This space is neurodivergent-affirming, self-diagnosis-friendly, and supportive of different communication styles and energy levels. Quiet participation is welcome. Listening is participating. Whether you're looking for support, learning, friendship, or simply a place where you don't have to explain yourself, you are welcome here. I look forward to meeting you. — Dawn

### **June Necromancer’s Awakening \| Free Undead Mini Event** Step into the grave this June with Necromancer’s Awakening at The Arcane Foundry. Join us for a paint and sip experience where you’ll receive a free undead miniature and explore the dark forces of necromancy in Warhammer Fantasy and The Old World. Whether you’re new to the hobby or a seasoned painter, this event invites you to raise something from the dead and make it your own. Learn techniques for painting bone, decay, ghostly effects, and weathered armor while diving into the lore and battlefield role of undead factions. From shambling skeletons to cursed revenants, you’ll bring a lifeless model to unholy existence. All supplies are provided, space is limited, and the dead are waiting to rise.

Our next much-awaited **COLUMBUS** meetup is **Tuesday June 30th from 7-10 pm EST at ACE OF CUPS**. Meet patients, cultivators, processors, dispensary managers/staff, physicians, home growers, educators, activists, nonprofits, artists, attorneys, business owners, writers, students, and supporters to network, share our knowledge, collaborate, support each other and make new ones! Hope you will be there too! Save the date and pass the word. **Please RSVP** so we know who is coming and how many to expect. Find us to say hi and we will introduce you to others. We should be easy to spot. (The happy-looking group wearing cool nametags! See photos from our past events.) Sign in, grab a name tag, start your own bar/food tab, meet old friends and make new ones! Everyone is welcome. SEE YOU THERE!

## Candle Making Night at The Arcane Foundry \| Design Your Own Custom Candle **SPECIAL PROMOTION**: Buy 3 and get 1 Free! Step into The Arcane Foundry and create your own custom candle from start to finish. This is a laid back, hands-on experience where **you’ll blend fragrances, choose your vessel, and pour your own candle using 100% soy wax**. Whether you’re coming solo or with friends, it’s designed to be simple, creative, and a good time. We’ll walk you through the entire process, from picking your scents to choosing between a traditional cotton wick or a crackling wood wick. You can go with one fragrance or mix your own blend to create something completely unique**. No experience needed**, just show up and we’ll handle the rest. While your candle sets, feel free to hang out, play a game, explore the shop, or just relax and talk. Drinks and snacks are available, and the atmosphere leans into the **fantasy**, **dark academia**, and **gothic horror** vibe The Arcane Foundry is known for. Learn More: [Candle Making in Columbus, Ohio at The Arcane Foundry](https://thearcanefoundry.com/candle-making/) *** ### What to Expect: * Guided candle making experience * Choose your own vessel, wax, wick, and fragrance * 100% soy wax candles * Optional drinks and snacks * Time to relax while your candle cools *** ### Important Notes: * Please arrive on time so we can start together * Candles will need time to set before taking home * This is a beginner-friendly event *** ### RSVP Required Reserve your spot on Meetup to lock in your seat. **Candle Making** (includes vessel, your choice of wick, wax, scented oil, labels and lids) 5oz Glass Jars $15 8oz Candle Tins $25 12oz Glass Candles $35 12oz Amber Jars $40 16 oz Skull or Jack o Lantern Candle Mugs $65 (Limited Edition!) **All materials included. You just bring yourself (and your drink of choice).** **Payments accepted:** * Credit Card * Venmo: @Daclaud-Lee * Cashapp: $DaclaudL

**🌷 Meet Port St. Lucie Singles Tonight — Zoom Speed Dating** No apps, no awkward bios. Just live one-on-one Zoom chats with Port St. Lucie singles picked for you. **What to expect:** - Register and take a short personality quiz - Jump on Zoom when the event starts - Meet singles in guided one-on-one rounds - Get your mutual matches by email afterward **Find your bracket and grab a seat:** → **Ages 18-32** — [Register here](https://theliveround.com/product?productId=573&productType=onlineSpeedDating&city=Port%20St.%20Lucie&groupurlname=manga-k-drama-foodie-language-feast-network&ar=18-32&face_v=8.0) → **Ages 30-46** — [Register here](https://theliveround.com/product?productId=573&productType=onlineSpeedDating&city=Port%20St.%20Lucie&groupurlname=manga-k-drama-foodie-language-feast-network&ar=30-46&face_v=8.0) → **Ages 40-58** — [Register here](https://theliveround.com/product?productId=573&productType=onlineSpeedDating&city=Port%20St.%20Lucie&groupurlname=manga-k-drama-foodie-language-feast-network&ar=40-58&face_v=8.0) → **Ages 55+** — [Register here](https://theliveround.com/product?productId=573&productType=onlineSpeedDating&city=Port%20St.%20Lucie&groupurlname=manga-k-drama-foodie-language-feast-network&ar=55+&face_v=8.0) > Heads up: an RSVP here does not hold your seat. Register through your age link and finish the quiz. Spots are capped. Register, relax, and let the night do the work. 😊

**✅ Bachata Mondays with Todd Smith!** **👉 Beginner Bachata Class** **$15 In Advance / $20 At the Door** . 7:00 pm – 7:15 pm … Registration 7:15 pm – 8:15 pm … Beginner Class . **👉 Intermediate Bachata Class** **= $15 In Advance / $20 At the Door** . 8:15 pm – 8:30 pm Registration 8:30 pm – 9:30 pm Intermediate Class . **👉 If You Take Both Bachata Classes** **= $25 In Advance / $35 At the Door** . **👉 Buy Advance Tickets Now at:** . https://columbussalsadancing.com/bachata-mondays-dance-class-tickets/

Welcome to Drunken Philosophy, a casual, curious, social discussion club. Come grab a drink and a seat at The Oracle. **Optional topic for this meetup: Where is everybody?** In 1950 the physicist Enrico Fermi was talking about aliens over lunch and asked a question that still has not gone away: if the universe is so vast and so old, and even a fraction of those billions of stars have planets, where is everyone? By the numbers the galaxy should be crowded with civilizations. Instead we look up and hear silence. That gap between "they should be everywhere" and "we see no one" is the Fermi Paradox. One of the most unsettling answers is the idea of a **Great Filter**: somewhere on the road from dead chemistry to a galaxy-spanning civilization, there is at least one step that is almost impossible to get past. Maybe the filter is behind us. Maybe life starting at all, or simple cells becoming complex, or intelligence ever evolving, is the freak accident, and we already cleared the hard part. Or maybe the filter is ahead of us, and advanced civilizations reliably wipe themselves out before they spread. Here is the part that messes with people. If we ever found life somewhere else, even pond scum on Mars, most people would call it the greatest discovery in history. But it might be the worst possible news. It would mean life is common, the early steps are easy, and the hard step is still in front of us. So the eerie silence overhead might actually be the best sign we could ask for. **Questions to wrestle with:** * Is it better to be alone? Would you rather we find alien life and learn we are not special, or find nothing and quietly improve our odds of surviving? * Where do you bet the filter sits, behind us or ahead of us, and why? * If it is ahead of us, what is it? Nuclear war, climate collapse, AI, something we cannot even picture yet? And can we do anything about a filter we cannot see coming? * Two principles pull opposite ways here. The principle of mediocrity (the Copernican principle, Sagan's "no privileged place in the universe") says we are ordinary, so what happened on Earth probably happened everywhere, which makes the silence scream louder. The anthropic principle says of course we find ourselves somewhere life was possible, since we could not observe anything else, so our being here may say almost nothing about how common life is. Which lens do you trust, and does the silence still demand an answer once you account for observer selection? * And if we did confirm life out there and had to accept we are not special, what would that do to belief in a higher power, and would shedding (or keeping) that belief help or hurt our odds of pulling together as one species? * Does any of this change how you live, or how humanity should be spending its time and money right now? As always the prompt is optional. Come for the conversation, stay for the drinks, and bring your own questions.