Informatics

Title: What Is Progress? Knowledge Aggregation, Living Textbooks, and the Automation of Scientific Discovery Date: June 20 2026 Noon - 14:00 EDT Summary: Our collective knowledge infrastructure — the textbooks, professional training resources, and literature syntheses that define what professionals across disciplines believe to be true — is quietly accruing a structural liability. Compounded confirmation bias, stacked citation-by-citation into the foundations of formal knowledge, means that breakthroughs can take decades to reach the classrooms, clinical workflows, and decision-making frameworks where they matter most. Meanwhile, the deepest friction is rarely acknowledged: before any field can build meaningful consensus on "why" or "how" a phenomenon occurs, it must first establish honest, consolidated agreement on "what" has actually been observed. That prior step is routinely skipped, assumed, or fragmented across siloed literatures that never cross-pollinate. This talk introduces a framework called "Knowledge Aggregation" — with two distinct but complementary ambitions. The first is descriptive transparency: algorithmically mapping what has been said, measured, and documented across a problem space, without imposing causal interpretation or narrative. The second traces the boundary between empirical observation and explanatory claim, building systems that can separate the "what" from the "why/how" — because consensus on mechanism cannot be meaningfully constructed until consensus on phenomenon is first established. Both ambitions are now within reach. By composing tools already at our disposal — large language models, classical NLP pipelines, public data repositories, and engineering-grade automation frameworks — it becomes possible to model knowledge itself, rather than merely imitate individual experts. One concrete expression of this is automating the writing of living textbooks: compressing the lag from bleeding-edge discovery, through replicated evidence, all the way to professional training resources. But the deeper aspiration reaches further — toward automating the discovery of scientific insights that have never previously been conceived, by systematically surfacing hypothesis combinations that no single siloed researcher would have had the cross-disciplinary vantage point to even ask. Drawing on ongoing systems biology and computational research — with ME/CFS research demoed as a use case for what siloed, fragmented knowledge infrastructure costs in practice — this talk maps the conceptual architecture, the real-world friction, and the data science toolkit for building it. Speaker: As a systems biologist at heart, Sam specializes his biomedical research on interactions and connections in biology - rather than just one domain of expertise. He wears many hats and collects skill sets across disciplines, with degree studies and industry experience acquired across Chemical Engineering (BSc), Bioinformatics (MSc), Systems and Synthetic Biology (M2), Biomedical Sciences (MSc), and beyond. Even more important to him than niches or fields of work, comes down to the synergistic approaches that allow us to move beyond reductionism. The notion that a question can only allow for one answer, is inherently reductionist. By resisting many norms in science and engineering which can get overly reductive, his current role as Principal Investigator of Research for DMV Petri Dish (501(c)(3) non-profit local to the DMV region) embraces computational frameworks that aide scale-up and automation - not only around the processes which already exist with established workflows, but also taking a keen interest in attempting and accomplishing ambitions which have never been perceived to be possible previously. Sam carries a passion for the synergy of computational biology - fused with wet lab validation. This way, one can build a beautiful knowledge base in the theoretical sense, and then test to see if said computational prediction might actually be able to stand in the real world with wet lab validation. Translational modeling starts to become possible once biological experiment design can be iteratively looped alongside computational model design, optimization, and analysis - empowering the design of a better wet lab experiment, followed by a better computational model, back and forth until science is done!

It is irresistible, to enjoy a GERMAN convo with drinks. ***GRAB A DRINK AND YOU ARE ALL SET TO FLEX YOUR LANGUAGE CAPACITY. YOU NEED TO GET AT LEAST A DRINK OR FOOD :) To get the event going and show support. We know that you like our events. P.S. : We have non-alcoholic drinks as well.*** We have a tiny venue and we hit capacity often and early arrival is suggested. We have the discretion to decide entry. HOW IT WORKS : We will try to assign tables for each represented languages and will direct attendees to their respective tables accordingly. Rules to abide : 1\. Event is 21\+ \(bring ID\)\. 2\. Be respectful to your counterparts and give them a chance to exchange with others as well\. 3\. We all are native speakers of one or two languages and be willing to help others and try to accommodate as much as possible\. 4\. If you don't speak the other person's required language\, LEAVE THEM ALONE\. 5\. Rude or aggressive members are removed from the group at an organizers discretion\. 6\. This is a face\-to\-face language exchange event\. DO NOT try to arrange an online meeting\, by using the comment box or direct message\. 7\. Most of our members complained about people writing in the comment box\. Since it sends notification to all attendees\. If you have any questions\, send a message to the organizers\. Don't write in the comment box\. 8\. We have ZERO TOLERANCE for solicitation\. We don't allow anyone to run their own agenda at the Event\. If you are interested to promote/sponsor/collaborate; contact us via \(info@merevents\.com\)\. 9\. When you get there\, we will greet you and take you to your respective group\. 10\. Don't be shy of your local languages\. We have diplomates assigned to different countries\, who would love to practice your languages\. 11\. Be patient for the first 30 minutes\, up until we form your respective language group\.
 12\. We will have a registration station and check you in\. 13\. This is mainly a social for Intermediate/Advanced/Native Speakers\. It is not as such to learn a language\. Beginners\, if you want to learn a language\, reach out to us \(info@merevents\.com\)\. We have a school and will arrange you a class\. ***AFTER THE EXCHANGE, WE HIT THE DANCE FLOOR! BRING YOUR DANCING SHOES, WE WILL DANCE THE NIGHT AWAY!***

NOTE: This working session is at West End Neighbourhood Library not MLK. It is near the Foggy Bottom Metro Station. A game development **Working Session** involves 3 key parts: 1. Tell people what you're going to do 2. Actually do stuff 3. Show people what you did **What to bring**: Laptop, Charger, maybe a power strip if you have one handy, any other game development tools you need. Try to download any software you need before the working session. There is Wifi at this location, but it may be slow if you have to download any large files.

Enjoy a lively German convo! Hoffentlich werden wir euch dort sehen! ***GRAB A DRINK AND YOU ARE ALL SET TO FLEX YOUR LANGUAGE CAPACITY. YOU NEED TO GET AT LEAST A DRINK OR FOOD :) To get the event going and show support. We know that you like our events. P.S. : We have non-alcoholic drinks as well.*** We have a tiny venue and we hit capacity often and early arrival is suggested. We have the discretion to decide entry. HOW IT WORKS : We will try to assign tables for each represented languages and will direct attendees to their respective tables accordingly. Rules to abide : 1\. Event is 21\+ \(bring ID\)\. 2\. Be respectful to your counterparts and give them a chance to exchange with others as well\. 3\. We all are native speakers of one or two languages and be willing to help others and try to accommodate as much as possible\. 4\. If you don't speak the other person's required language\, LEAVE THEM ALONE\. 5\. Rude or aggressive members are removed from the group at an organizers discretion\. 6\. This is a face\-to\-face language exchange event\. DO NOT try to arrange an online meeting\, by using the comment box or direct message\. 7\. Most of our members complained about people writing in the comment box\. Since it sends notification to all attendees\. If you have any questions\, send a message to the organizers\. Don't write in the comment box\. 8\. We have ZERO TOLERANCE for solicitation\. We don't allow anyone to run their own agenda at the Event\. If you are interested to promote/sponsor/collaborate; contact us via \(info@merevents\.com\)\. 9\. When you get there\, we will greet you and take you to your respective group\. 10\. Don't be shy of your local languages\. We have diplomates assigned to different countries\, who would love to practice your languages\. 11\. Be patient for the first 30 minutes\, up until we form your respective language group\.
 12\. We will have a registration station and check you in\. 13\. This is mainly a social for Intermediate/Advanced/Native Speakers\. It is not as such to learn a language\. Beginners\, if you want to learn a language\, reach out to us \(info@merevents\.com\)\. We have a school and will arrange you a class\. ***AFTER THE EXCHANGE, WE HIT THE DANCE FLOOR! BRING YOUR DANCING SHOES, WE WILL DANCE THE NIGHT AWAY!***

This will be our kick-off meeting. Mostly, this is to get to know one another, and to figure out what everyone is looking for with the group and meetings. Newcomers to Linux and Free Software are always welcome, so please feel free to spread the word! Note, the room I was hoping to use in Wheaton is in extremely high demand, so this will be at the Silver Spring Library (Brigadier General Charles E. McGee Library), in Small Room 2. Unfortunately, parking is ***not*** free on Saturdays, and is $1.25/hour.

Hello Everyone, Thank you so much for joining us for our **Valentine’s Mystery Social**! It was truly a pleasure to host such an intentional space for all of you to connect as "souls" rather than just titles and paychecks. We heard your feedback loud and clear: you all wanted more time to connect after the opening icebreakers! We have noted this and look forward to hosting several more of these sessions for our private clients throughout the year with even more space for deep discussion. ### **🔥 TODAY ONLY: Elite Match Alert** We have just added two profiles, a powerhouse Jack and Jill **brother and sister duo**—both exceptional catches: * **The Sports Agent (Male):** A high-achieving, family-oriented professional who embodies the values of our community and the legacy of his upbringing. * **The Powerhouse Attorney (Female):** A stunning attorney and active actress who is a true "Jack and Jill" legacy. She balances a high-stakes legal career with a passion for the arts. **Follow us on IG:** For our most up-to-date match alerts and event BTS, make sure you are following us on Instagram @helpmeetclub **Saturday Appointment Available:** We have **ONE** consultation opening available for this Saturday. This is first-come, first-served for anyone ready! **Consultation:** To celebrate these new additions, use code FRIENDS20 at checkout for an **[additional $55.55 off](https://thehelpmeetclub.com/join-our-database-of-singles-form/)**[ ](https://thehelpmeetclub.com/join-our-database-of-singles-form/)our current consult special. **This code is valid TODAY ONLY.** ### **Action Required: Selection Form** Please submit your final selections by the **end of today**. As a reminder, we only facilitate a "Double-Yes" match (where both parties select each other) or reach out if you have specifically marked that you are open to hearing from others. ### **Membership Updates** We are committed to the quality of our community. To that end, we have decided to make some adjustments to our membership structure: * **Database Services:** We will no longer allow women to join our database as a standalone service. * **The Reason:** It is undeniable that the women who complete our **Readiness Process** stand out and make exceptional partners. It is only fair that they are rewarded with exclusive access to our socials and curated community. On that note, if your database membership is currently expiring, please let us know and we will re-enroll you at 50% off your annual database membership fee.

[Book Your Classes by Clicking This Link! ](https://crowndancestudio.com/group-classes/) Take a deep dive into the world of Latin rhythm with our **Level 2 Bachata workshop from 1:30 PM to 3:00 PM**. This 90-minute intensive is crafted for dancers who have moved past the basics and are ready to refine their body mechanics, intricate footwork, and partner connection. **For $25,** you’ll receive focused, high-value instruction that bridges the gap between foundational steps and social dance mastery, ensuring you leave the studio feeling confident and inspired

We'll check out 29th Parallel Coffee in Fairfax Station. We plan to grab a coffee and head to Burke Lake Park and walk around the lake (weather permitting). There are a couple of parking areas at the park. I marked the parking we're planning to meet at the park. We hope to start the walk around 11:30AM. If you're a Fairfax County resident (with an ID), parking is free, otherwise they charge for parking. Please have a picture profile so we can recognize you in the meetup.

Hey Poetry Lovers! This group is on a roll. Here’s the gist: We meet at the **Capital One Café in Chinatown** from **12pm - 2pm** every other week. For enrichment, we start by reading and reflecting on a **“published poem”**, suggested by someone in the group. No advance preparation is necessary. But feel free to check out some of the poems we’ve read [here](https://docs.google.com/spreadsheets/d/e/2PACX-1vSyE_wCLQCPHRrKmN5F9tOIeeRQUZESxjRXGVBoCF2uU8Gm0_d0uECiCBCQXEy6ksxfsBOhtRIOpW3T/pubhtml?gid=0&single=true&widget=true&headers=false%22%3E%3C/iframe%3E). Or submit suggestions for future meetings [here](https://docs.google.com/forms/d/e/1FAIpQLSexGc2Z2Kp6bZW0D3_hfJ7NUUkfNHf7TXX-43FglCeBd9EF2Q/viewform?usp=send_form). Next, we **share our work and offer feedback**. Depending on attendance, everyone gets \~10 minutes to use as they like. (No need to share, though; you’re welcome to come even if you prefer just to listen.) We maintain a **Discord server** to help share our work and communicate outside our bi-weekly meet-ups. If you haven’t used Discord before, take a moment to download it and create an account before arriving. When we meet you on Saturday, we will add you to our server, the “DC Poetry Workshop”, and can help you navigate the app if you have questions. Finally, if you plan on sharing a poem, consider how you will do so. Some options include: * Print 5-10 copies to distribute in person * Take and share screenshots in the Discord chat. * Copy the poem into a google doc, change sharing settings to “anyone with link”, and copy the google doc link into the Discord chat. Most importantly, we’re excited to meet you! Catch you on Saturday, Diego / Ian / Cayden / Nate / Otasha / Lia / An

Join us on zoom call zoom from your phone free at 1929 436 2866; meeting id is 896 0197-4108 that's all, see you today 3rd Sunday at 12:45pm 2-15-26 ask for Howard!

Come exchange Asian Languages that you speak! ***GRAB A DRINK AND YOU WILL BE ALL SET TO FLEX YOUR LANGUAGE CAPACITY. YOU NEED TO GET AT LEAST A DRINK OR FOOD :) To get the event going and show support. We know that you like our events. P.S. : We have non-alcoholic drinks as well.*** We have a tiny venue and we hit capacity often and early arrival is suggested. We have the discretion to decide entry. We will assign tables for represented languages. All languages are welcome! However we don't guarantee the availability of a partner in that particular language, you would like to exchange. As you all remember well, this event used to bring out hundreds of people every week. However, it was discontinued last year for obvious reasons and we couldn't gather that many people now, because of restrictions. Hence, we are downsizing and caping the number of attendees. We have super limited spots and advance ticket purchase is required. ***AFTER THE HAPPY HOUR, WE HIT THE DANCE FLOOR! BRING YOUR DANCING SHOES, WE WILL DANCE THE NIGHT AWAY!*** HOW IT WORKS : We will try to assign tables for each represented languages and will direct attendees to their respective tables accordingly. All languages are welcome! However we don't guarantee the availability of a partner in that particular language, you would like to exchange. Rules to abide : 1. Event is free and 21+ (bring ID). 2. Be respectful to your counterparts and give them a chance to exchange with others as well. 3. We all are native speakers of one or two languages and be willing to help others and try to accommodate as much as possible. 4. If you don't speak the other person's required language, LEAVE THEM ALONE. 5. Rude or aggressive members are removed from the group at an organizers discretion. 6. This is a face-to-face language exchange event. DO NOT try to arrange an online meeting, by using the comment box or direct message. 7. Most of our members complained about people writing in the comment box. Since it sends notification to all attendees. If you have any questions, send a message to the organizers. Don't write in the comment box. 8. We have ZERO TOLERANCE for solicitation. We don't allow anyone to run their own agenda at the Event. If you are interested to promote/sponsor/collaborate; contact us via (info@merevents.com). 9. When you get there, we will greet you and take you to your respective group. 10. Don't be shy of your local languages. We have diplomates assigned to different countries, who would love to practice your languages. 11\. Be patient for the first 30 minutes\, up until we form your respective language group\. 12\. We will have a registration station and check you in\. You ought to have register on Meetup for a free entry\. Otherwise\, you will be subject to a cover charge\. 11. 13\. This is mainly a social for Intermediate/Advanced/Native Speaker\. It is not as such to learn a language\. Beginners\, if you want to learn a language\, reach out to us \(info@merevents\.com\)\. We have a school and will arrange you a class\. 12.

Let's get together to play some competitive quads and doubles volleyball. **COST**: FREE **Court Type**: Outdoor grass **Minimum Skill Requirements**: Intermediate (click [here](https://docs.google.com/document/d/1PojSi4qdlRsv1msCHhvpQ43iDc4FfzQwpWCc3kafVMY/mobilebasic) for details) Attention: 1. This event is **NOT on a first come-first serve** basis and players with higher skill level and players who can bring a net/ball will get priority over others on the wait list. 2. Since skill levels are **self-reported**, some new attendees may not meet the expected level. For doubles, we encourage you to choose a partner you can enjoy the game with, and since this a competitive event, it is okay if you make a strong team and win all the games. 3. Each person must help set up and take down one net, leaving some nets unset for latecomers. 4. Please answer all questions, so it's helpful for us to organize the event. **Smiley Social documents:** 1. [Group Rules](https://docs.google.com/document/d/1HrG35p_0M08leRvCp8XWG3CMkr_GL928XFabl5T6Dvg) 2. [Smiley Social Volleyball Levels](https://docs.google.com/document/d/1PojSi4qdlRsv1msCHhvpQ43iDc4FfzQwpWCc3kafVMY/edit) 3. [Good doubles partner](https://docs.google.com/document/d/14weEw-P52XKx0P8K2l-ZOFtYU61wmfdkSkopbG5avro/) 4. [Liability Waiver](https://docs.google.com/document/d/1W2mq-7m99lmvd7gdWYaSUFtvVg4UGnzV6koafAbHmco)

Socrates Cafés are gatherings around the world where people from different backgrounds get together and exchange thoughtful ideas and experiences while embracing the Socratic Method; the idea that we learn more when we question, and question with others. Although this may be considered a "philosophical" group, there are no rules as to what is discussed. Those attending decide upon the questions of the night. Usually, the topics revolve around social concerns, moral issues, and the first principles of things. Prior to each meeting we vote online for the questions we will discuss. That way, we will have enough time to ruminate on them and have more in-depth conversations. If you RSVP to a meeting, you may post your question in the event comments section below. I'll send out a survey for voting a few days prior to the meetup. We discuss two questions each night. So you will get to cast two votes in the survey. When we meet, we break into smaller groups of five to seven to discuss the top two vote-getters. Each group discusses one question for around 45-50 minutes, and we then take a short break. After reconvening, each group moves on to its second question. Hope to see you there! -Brian

Christians in Tech is a community at the intersection of faith and technology. Our meetups are designed to spark meaningful conversations, promote knowledge sharing, and encourage growth—both in your career and your spiritual walk with God. Whether you're an experienced professional or just starting your tech journey, CIT welcomes you. Our Website [https://linktr.ee/citcbus](https://linktr.ee/citcbus) Sponsors and Partners * Improving (Venue Sponsor) * Bethel World Prayer Center (Fiscal Sponsor) * Fruits & Roots (Coffee Partner)

We are bringing Microsoft Build sessions to Columbus Ohio! The Central Ohio Azure Meetup and Central Ohio .NET Developer's Group (CONDG) are coming together to bring some of the labs and breakouts from Microsoft Build to your backyard. In this free, 1 day event, you are going to Build stuff with us! And yes, there will be free food. Please RSVP via [Microsoft Build //localhost:columbus | Microsoft Reactor](https://developer.microsoft.com/en-us/reactor/events/27247/).

Join us for the Germany vs Ivory Coast World Cup Watch Party in the beer garden at Land Grant. As an outdoor event, it will be dependant on weather. Kick off is at 4:00. (Message me if you are interested in biking to Land Grant from the Grandview area.)

**Improving Office in Franklinton** Physical location: Improving Office 330 Rush Alley Suite #150 Columbus, OH 43215 Schedule: 6:00 p.m.: Socialize, eat, and drink. Improving will be providing pizza and beverages. 6:30 to 8:00 pm. Main meeting and presentation(s). Topic: This month Chris Pazsint will be talking about Agentic Coding. How does one use CLI Based Agents, and Agentic IDEs such as Cursor, Kiro, Antigravity? How to include agentic coding plugins for IDEs you already love such as Visual Studio Code. We meet on the last Monday of each Month. Presentations are given by members and friends of this group. If you would like to do a presentation (small or large) on a python topic, please contact Central OH Python at centralohpython@gmail.com

**🎵 Tonight in Fort Wayne: Speed Date From Your Sofa** > Six minutes. One screen. A room full of Fort Wayne singles matched to your vibe. It all happens on Zoom. **It runs like this:** 🔹 Drop your details and zip through a quick personality quiz 🔹 Log into Zoom right at go-time 🔹 Cycle through short one-on-ones with Fort Wayne singles 🔹 Check your inbox tomorrow — your matches will be waiting --- **Select your age group to lock in a place:** 🔸 **Ages 18-32** → [Claim your spot](https://theliveround.com/product?productId=574&productType=onlineSpeedDating&city=Fort%20Wayne&groupurlname=german-conversation-circle-sparks-new-friendships&ar=18-32&face_v=9.0) 🔸 **Ages 30-46** → [Claim your spot](https://theliveround.com/product?productId=574&productType=onlineSpeedDating&city=Fort%20Wayne&groupurlname=german-conversation-circle-sparks-new-friendships&ar=30-46&face_v=9.0) 🔸 **Ages 40-58** → [Claim your spot](https://theliveround.com/product?productId=574&productType=onlineSpeedDating&city=Fort%20Wayne&groupurlname=german-conversation-circle-sparks-new-friendships&ar=40-58&face_v=9.0) 🔸 **Ages 55+** → [Claim your spot](https://theliveround.com/product?productId=574&productType=onlineSpeedDating&city=Fort%20Wayne&groupurlname=german-conversation-circle-sparks-new-friendships&ar=55+&face_v=9.0) _Reminder: RSVP on Meetup doesn't get you a seat. You need to register through your age link and complete the quiz. Numbers are capped._ --- No swiping. No ghosting. Just good conversation. 🪩

Most people still use AI like a search box: type one question, get one answer, repeat. But the next step is AI agents: systems that can take a goal, break it into steps, use tools, remember context, and produce useful work for a human to review. In this beginner-friendly session, we’ll demystify what AI agents actually are — without hype or jargon. We’ll walk through practical examples of how agents can help with research, planning, writing, coding, operations, and personal productivity. We’ll cover: * What makes an AI “agent” instead of just a chatbot * How agents break tasks into steps * Where agents are genuinely useful today * Where they fail, hallucinate, or need human review * How to design simple AI workflows for your own work * A live demo of an AI agent-style workflow from start to finish No coding experience required. This is for anyone who wants to understand where AI tools are going and how to use them more effectively right now. LOGISTICS AND PARKING: The talk starts at 7:00 PM. The first half hour is reserved for everyone to get set up and mingle. Free pizza and drinks! The cheapest parking option is to find street parking, which will only cost you a few bucks. Otherwise, park in the nearby veteran's museum lot for $8. It's highly recommended you avoid the nearby $15 garage parking.

**Join Katie McCartney, SRES®, for a clear and easy‑to‑understand update on what the 2026 Central Ohio housing market means for seniors and their families.** Whether you’re planning ahead, helping a parent make decisions, or simply trying to understand today’s market, this session offers reliable insights without pressure or overwhelm. During this free class, Katie will break down the trends shaping housing for older adults in Central Ohio, explain what families should realistically expect in 2026, and answer your questions during an open Q&A. This is a supportive, information‑focused workshop designed to give you confidence and clarity — no sales pitch, just helpful guidance. *** **Ideal for:** * Seniors considering future housing options * Adult children supporting aging parents * Anyone seeking a calm, trustworthy source of market information *** **What You’ll Learn:** * A senior‑friendly look at the 2026 Central Ohio housing market * Personalized answers during an open Q&A You’ll leave with a better understanding of your options and your next steps. *** **Hosted by:** **Katie McCartney, Broker & Senior Real Estate Specialist® (SRES) with** Pillar Realty, LLC Compassionate guidance for seniors navigating housing transitions in Central Ohio. *** **Location:** Columbus Metropolitan Library: Dublin Branch 75 N High St, Dublin, OH 43017 ([https://maps.app.goo.gl/GL2vbJgUHqTncbHZ9](https://maps.app.goo.gl/GL2vbJgUHqTncbHZ9)) Meeting Room 3 **Doors Open:** 1 PM **Seats:** Limited Seating (first come, first served) **Cost:** Complimentary