I've worked in the industry for years, this is not a 'set it and forget it' issue.
You need an email deliverability person that takes care of whitelisting your IPs with different providers. You'll need to do canspam compliance and constantly be checking deliverability reporting as well as reputation metrics.
Also make sure your lists are clean as it only takes a couple of spam traps to blacklist you.
Having a prominent and visible 'unsubscribe' link helps avoid getting hit with the spam button (decreasing your reputation), though people don't have much trust in these.
In any case, sending 10K email should really not get you blocked unless you are doing it constantly or have a high rate of being reported as spam.
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