BayBifx May 10 @CircuitLaunch!

We will be holding a really exciting event on Wednesday, May 10th, at Circuit Launch!

Agenda

• Arrival / Snacks (6-6:15pm)
• Intro - Circuit Launch
• Peter Karp, SRI (Keynote Speaker) - "Expanding the Paradigm of Microbial Genome Annotation"
• Eyal Akiva, Shiru - "AI-enabled discovery of functional ingredients for the global food industry"
• Trent Hauck, Where True Technologies - "Moving Bioinformatics into SQL, a New Approach to Expand Capabilities"
• Round Table, Longevity Start-Ups, Opportunities & Funding
• Alex Kadet, Gero.AI
• Mark Hamalainen, Longevity Biotech Fellowship
• Chris Patil, BioAge
• Announcements
• Lab Tour, Circuit Launch (~8pm)
• Networking & Refreshments

Ample parking available.
This event will be recorded.

Abstract for Peter Karp's talk:
Expanding the Paradigm of Microbial Genome Annotation
Peter D. Karp, SRI International
Our ability to computationally interpret sequenced genomes has gone far beyond what was envisioned in the early years of the human genome project. An early milestone was the "standard" paradigm for computationally analyzing a newly sequenced microbial genome: assemblers combine sequencer reads into longer contigs; gene-finding programs identify the locations of genes within those contigs; sequence-similarity searches and HMM models assign functions to the genes. In recent years that paradigm has been extended in multiple respects through the development of inference tools that extract additional information from the genome: metabolic reconstruction techniques predict the qualitative metabolic network of the organism, and generate a quantitative metabolic model for the organism.
Pathway hole filling and reaction gap filling tools identify genes coding for missing pathway enzymes, and identify missing metabolic reactions. Additional tools infer operons, transport reactions, and protein complexes.
After reviewing this expansion in the microbial genome-annotation paradigm I will present a new component of the Pathway Tools software behind BioCyc: the Comparative Genome Dashboard, a visualization tool for functional comparisons of genomes.