Vascular dysfunction and inflammation in Alzheimer's disease

IMPORTANT NOTE - To attend, please register on Brain & Cognitive Science Seminars page here:
https://www.meetup.com/brain-and-cognitive-science-seminar/events/305837343/?eventOrigin=group_upcoming_events

Although the exact causes of Alzheimer's disease are still unknown, we are learning that not having enough nutrition supply from the blood vessels can be one contributing factor. A recent paper showed some biological mechanisms that cause blood vessel dysfunction and inflammation in Alzheimer's disease, and proposed a potential treatment to prevent or slow the disease. I will discuss some key findings from this paper in the bigger context of Alzheimer's disease and dementia.

Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia
https://www.nature.com/articles/s41593-024-01753-w

A more digestible summary can be found here:
Pericyte relaxation boosts cerebral blood flow
https://www.nature.com/articles/s41583-024-00873-3
(apologies if this is not accessible to all!)

An even more accessible news article is here:
https://www.news-medical.net/news/20240923/Calcium-channel-blockers-show-potential-to-restore-cerebral-blood-flow-in-Alzheimers-disease.aspx