Machine Learning

Title: What Is Progress? Knowledge Aggregation, Living Textbooks, and the Automation of Scientific Discovery Date: June 20 2026 Noon - 14:00 EDT Summary: Our collective knowledge infrastructure — the textbooks, professional training resources, and literature syntheses that define what professionals across disciplines believe to be true — is quietly accruing a structural liability. Compounded confirmation bias, stacked citation-by-citation into the foundations of formal knowledge, means that breakthroughs can take decades to reach the classrooms, clinical workflows, and decision-making frameworks where they matter most. Meanwhile, the deepest friction is rarely acknowledged: before any field can build meaningful consensus on "why" or "how" a phenomenon occurs, it must first establish honest, consolidated agreement on "what" has actually been observed. That prior step is routinely skipped, assumed, or fragmented across siloed literatures that never cross-pollinate. This talk introduces a framework called "Knowledge Aggregation" — with two distinct but complementary ambitions. The first is descriptive transparency: algorithmically mapping what has been said, measured, and documented across a problem space, without imposing causal interpretation or narrative. The second traces the boundary between empirical observation and explanatory claim, building systems that can separate the "what" from the "why/how" — because consensus on mechanism cannot be meaningfully constructed until consensus on phenomenon is first established. Both ambitions are now within reach. By composing tools already at our disposal — large language models, classical NLP pipelines, public data repositories, and engineering-grade automation frameworks — it becomes possible to model knowledge itself, rather than merely imitate individual experts. One concrete expression of this is automating the writing of living textbooks: compressing the lag from bleeding-edge discovery, through replicated evidence, all the way to professional training resources. But the deeper aspiration reaches further — toward automating the discovery of scientific insights that have never previously been conceived, by systematically surfacing hypothesis combinations that no single siloed researcher would have had the cross-disciplinary vantage point to even ask. Drawing on ongoing systems biology and computational research — with ME/CFS research demoed as a use case for what siloed, fragmented knowledge infrastructure costs in practice — this talk maps the conceptual architecture, the real-world friction, and the data science toolkit for building it. Speaker: As a systems biologist at heart, Sam specializes his biomedical research on interactions and connections in biology - rather than just one domain of expertise. He wears many hats and collects skill sets across disciplines, with degree studies and industry experience acquired across Chemical Engineering (BSc), Bioinformatics (MSc), Systems and Synthetic Biology (M2), Biomedical Sciences (MSc), and beyond. Even more important to him than niches or fields of work, comes down to the synergistic approaches that allow us to move beyond reductionism. The notion that a question can only allow for one answer, is inherently reductionist. By resisting many norms in science and engineering which can get overly reductive, his current role as Principal Investigator of Research for DMV Petri Dish (501(c)(3) non-profit local to the DMV region) embraces computational frameworks that aide scale-up and automation - not only around the processes which already exist with established workflows, but also taking a keen interest in attempting and accomplishing ambitions which have never been perceived to be possible previously. Sam carries a passion for the synergy of computational biology - fused with wet lab validation. This way, one can build a beautiful knowledge base in the theoretical sense, and then test to see if said computational prediction might actually be able to stand in the real world with wet lab validation. Translational modeling starts to become possible once biological experiment design can be iteratively looped alongside computational model design, optimization, and analysis - empowering the design of a better wet lab experiment, followed by a better computational model, back and forth until science is done!

We'll be offering a Free Learn to Skate Clinic 10am Saturday next to the Carter Barron Amphitheatre parking lot in Rock Creek Park. We'll cover everything you need to start skating outdoors. Inline and roller skaters welcome; protective gear required (check our meetup group description for details). We have loaner skates and protective gear available. If you need to borrow gear, please contact us at least a couple of days in advance of this session so we'll know to bring it for you. If you need skates, please specify roller skates or inlines and also men's or women's sizes. A note on our start time: * Please be there by 930am if you plan to borrow gear so you have enough time to try things on and make sure everything fits. * Please be there by 945am if you have your own gear so you have enough time to put it on. * The clinic starts promptly at 10am; if you're not geared up and ready when we start, it'll be hard to include you in the session.

[Book Your Classes by Clicking This Link! ](https://crowndancestudio.com/group-classes/) Take a deep dive into the world of Latin rhythm with our **Level 2 Bachata workshop from 1:30 PM to 3:00 PM**. This 90-minute intensive is crafted for dancers who have moved past the basics and are ready to refine their body mechanics, intricate footwork, and partner connection. **For $25,** you’ll receive focused, high-value instruction that bridges the gap between foundational steps and social dance mastery, ensuring you leave the studio feeling confident and inspired

Venez apprécier l'ambiance chaleureuse d'une conversation en français autour d'un verre de vin et d'apéritifs. C'est ouvert à tous quelque soit votre niveau, que vous soyez intermédiaire/avancé ou bien que le Français soit votre langue maternelle. ***GRAB A DRINK AND YOU WILL BE ALL SET TO FLEX YOUR LANGUAGE CAPACITY. YOU NEED TO GET AT LEAST A DRINK OR FOOD :) To get the event going and show support. We know that you like our events. P.S. : We have non-alcoholic drinks as well.*** We have a tiny venue and we hit capacity often and early arrival is suggested. We have the discretion to decide entry. It is irresistible, to enjoy French convo with a glass of wine, appetizers and drinks. The Event is open to all levels of French language, from intermediate to native fluency. This is mainly a social for Intermediate/Advanced/Native Speakers. It is not as such to learn a language. Beginners, if you want to learn a language, reach out to us ([info@merevents.com](http://info@merevents.com/)). We have a school and will arrange you a class. ***AFTER THE HAPPY HOUR, WE HIT THE DANCE FLOOR! BRING YOUR DANCING*** [http://www.youtube.com/watch?v=6Vv1wxZAR1k](http://www.youtube.com/watch?v=6Vv1wxZAR1k)

We'll check out 29th Parallel Coffee in Fairfax Station. We plan to grab a coffee and head to Burke Lake Park and walk around the lake (weather permitting). There are a couple of parking areas at the park. I marked the parking we're planning to meet at the park. We hope to start the walk around 11:30AM. If you're a Fairfax County resident (with an ID), parking is free, otherwise they charge for parking. Please have a picture profile so we can recognize you in the meetup.

Learn to manage stress and achieve self-growth through simple relaxation and Meditation. Heartfulness Meditation is a simple, modern, methodical approach to meditation. Rather than homing in on your breath or repeating a mantra, you simply focus inward, on your heart, to cultivate inner strength and serenity. Heartfulness meditation is gaining traction in recent years. It focuses on the heart, allowing individuals to connect with themselves on a deeper level, and ultimately achieve peace, relaxation, and clarity. It is a practice that encourages patience, self-compassion, and acceptance, helping cultivate a deeper appreciation for the present moment. This practice is offered with love and at no cost

Discover the path to stress management, life's tranquility, and self-improvement through Heartfulness Meditation. Embrace relaxation, meditation, and emotional detoxification practices to unlock your best self. Join our free sessions every Sunday at 8 AM and Wednesday at 7 / 7:30 PM at various centers in MD and VA. Experience the profound benefits of these simple yet powerful practices. Commit to a few months of meditation and witness the transformative impact firsthand. We eagerly await your presence at these enlightening sessions.

Let's get together to play some competitive quads and doubles volleyball. **COST**: FREE **Court Type**: Outdoor grass **Minimum Skill Requirements**: Intermediate (click [here](https://docs.google.com/document/d/1PojSi4qdlRsv1msCHhvpQ43iDc4FfzQwpWCc3kafVMY/mobilebasic) for details) Attention: 1. This event is **NOT on a first come-first serve** basis and players with higher skill level and players who can bring a net/ball will get priority over others on the wait list. 2. Since skill levels are **self-reported**, some new attendees may not meet the expected level. For doubles, we encourage you to choose a partner you can enjoy the game with, and since this a competitive event, it is okay if you make a strong team and win all the games. 3. Each person must help set up and take down one net, leaving some nets unset for latecomers. 4. Please answer all questions, so it's helpful for us to organize the event. **Smiley Social documents:** 1. [Group Rules](https://docs.google.com/document/d/1HrG35p_0M08leRvCp8XWG3CMkr_GL928XFabl5T6Dvg) 2. [Smiley Social Volleyball Levels](https://docs.google.com/document/d/1PojSi4qdlRsv1msCHhvpQ43iDc4FfzQwpWCc3kafVMY/edit) 3. [Good doubles partner](https://docs.google.com/document/d/14weEw-P52XKx0P8K2l-ZOFtYU61wmfdkSkopbG5avro/) 4. [Liability Waiver](https://docs.google.com/document/d/1W2mq-7m99lmvd7gdWYaSUFtvVg4UGnzV6koafAbHmco)

Hey Poetry Lovers! This group is on a roll. Here’s the gist: We meet at the **Capital One Café in Chinatown** from **12pm - 2pm** every other week. For enrichment, we start by reading and reflecting on a **“published poem”**, suggested by someone in the group. No advance preparation is necessary. But feel free to check out some of the poems we’ve read [here](https://docs.google.com/spreadsheets/d/e/2PACX-1vSyE_wCLQCPHRrKmN5F9tOIeeRQUZESxjRXGVBoCF2uU8Gm0_d0uECiCBCQXEy6ksxfsBOhtRIOpW3T/pubhtml?gid=0&single=true&widget=true&headers=false%22%3E%3C/iframe%3E). Or submit suggestions for future meetings [here](https://docs.google.com/forms/d/e/1FAIpQLSexGc2Z2Kp6bZW0D3_hfJ7NUUkfNHf7TXX-43FglCeBd9EF2Q/viewform?usp=send_form). Next, we **share our work and offer feedback**. Depending on attendance, everyone gets \~10 minutes to use as they like. (No need to share, though; you’re welcome to come even if you prefer just to listen.) We maintain a **Discord server** to help share our work and communicate outside our bi-weekly meet-ups. If you haven’t used Discord before, take a moment to download it and create an account before arriving. When we meet you on Saturday, we will add you to our server, the “DC Poetry Workshop”, and can help you navigate the app if you have questions. Finally, if you plan on sharing a poem, consider how you will do so. Some options include: * Print 5-10 copies to distribute in person * Take and share screenshots in the Discord chat. * Copy the poem into a google doc, change sharing settings to “anyone with link”, and copy the google doc link into the Discord chat. Most importantly, we’re excited to meet you! Catch you on Saturday, Diego / Ian / Cayden / Nate / Otasha / Lia / An

**\*\*\* NOTE change of library space - We're meeting at Dolley Madison Library in McLean VA for this meeting \*\*\*** *theme:* **Power\, Voice & Stable Strength \| The Way of the Superior Man** Well explore themes from David Deida's book **The Way of the Superior Man** & his other teachings To simplify **David Deida’s approach** to owning your power, voice, stability, and strength, think of it as moving from performing a persona to radiating your deepest truth through an open body and a clear purpose. * **Owning Your Power**: Stop Resisting the Moment The Concept: True power isn’t about control; it’s the force that flows when you stop hiding from your fears. The Action: Unclench your body. Soften your belly and jaw so your energy isn't trapped. Reclaim your "dark masculine"—the warrior spirit that is willing to face death for the sake of love. * **Owning Your Voice**: Speak to Open Hearts The Concept: Your words are a musical instrument designed to change the energy of the room. The Action: Maintain integrity. Speak with absolute clarity and make sure your actions always match your word. Use your speech as a gift to open the hearts of those listening. * **Owning Your Stability:** Be Uncollapsable The Concept: Stability is being grounded in the "mystery of life and death" rather than surface-level tasks. The Action: Remain unperturbed. Don’t let your partner’s emotional storms or the world’s chaos "sag" your life. When tested, stay centered in your purpose rather than collapsing for approval. **Psychodynamic shared exploration, learning and growth** Interpersonal process groups focus on the interactions and dynamics between group members to facilitate personal growth and learning. These groups provide a courageous space for individuals to explore their interpersonal patterns, receive feedback, and develop more effective social skills. **The core principle is that the group itself becomes a microcosm of a member's real-life relationships, allowing for insights and behavioral changes.** Key aspects of interpersonal process groups: * **Exploration of Interpersonal Dynamics:** Members examine their communication styles, relationship patterns, and how they relate to others within the group. * **Feedback and Self-Awareness:** The group provides a platform for members to receive feedback on their behaviors and develop greater self-awareness. * **Development of Social Skills:** Members practice new ways of relating, communicating, and collaborating within the group, leading to improved social skills. * **Microcosm of Relationships:** The group mirrors real-life relationships, allowing members to observe and analyze their patterns in a safe and controlled setting. * **Personal Growth and Well-being:** Through these processes, individuals can experience significant personal growth and enhanced well-being. Benefits of participating in an interpersonal process group: * **Increased self-awareness:** Understanding one's own behavior and its impact on others. * **Improved communication skills:** Learning to communicate more effectively and assertively. * **Stronger relationships:** Developing more fulfilling and meaningful relationships. * **Enhanced empathy and understanding:** Learning to see situations from others' perspectives. **Tentative Agenda:** 1:00pm Social, Setup & Introductions, guidelines, terminology; 1:15pm Interactive open dialogue conversation & sharing; 2:45pm debrief, summary, debrief 3:00pm finish Light snacks, candy & water provided. Dolley Madison Library is in McLean, VA near I-495 beltway exits 44, 45 or 46. **Meeting Room** **#2** is 2nd door on immediate right after entering.

Come join us for the weekly open mic night and enjoy a mix of comedy, poetry, and music!

**THE POWER OF THE SUBCONSCIOUS OVER YOU** You are welcome to arrive 15 minutes early for refreshments! At the lecture "The Power of the Subconscious", the speaker will clearly and understandably explain topics such as: * What is the exact definition of the Subconscious Mind? * How does it inflict unwanted feelings and anxiety in you? * What determines how much pressure it exerts on a person? * What exactly is the goal of the subconscious? This is not just a lecture where you sit quietly and listen. It's interactive and LIVE, so you can ask questions at any time. And the most important topic: **HOW DO YOU TAKE CONTROL OF YOUR SUBCOUNSCIOUS!** This group is sponsored by the Dianetics Life Improvement Center.

Most people still use AI like a search box: type one question, get one answer, repeat. But the next step is AI agents: systems that can take a goal, break it into steps, use tools, remember context, and produce useful work for a human to review. In this beginner-friendly session, we’ll demystify what AI agents actually are — without hype or jargon. We’ll walk through practical examples of how agents can help with research, planning, writing, coding, operations, and personal productivity. We’ll cover: * What makes an AI “agent” instead of just a chatbot * How agents break tasks into steps * Where agents are genuinely useful today * Where they fail, hallucinate, or need human review * How to design simple AI workflows for your own work * A live demo of an AI agent-style workflow from start to finish No coding experience required. This is for anyone who wants to understand where AI tools are going and how to use them more effectively right now. LOGISTICS AND PARKING: The talk starts at 7:00 PM. The first half hour is reserved for everyone to get set up and mingle. Free pizza and drinks! The cheapest parking option is to find street parking, which will only cost you a few bucks. Otherwise, park in the nearby veteran's museum lot for $8. It's highly recommended you avoid the nearby $15 garage parking.

**Improving Office in Franklinton** Physical location: Improving Office 330 Rush Alley Suite #150 Columbus, OH 43215 Schedule: 6:00 p.m.: Socialize, eat, and drink. Improving will be providing pizza and beverages. 6:30 to 8:00 pm. Main meeting and presentation(s). Topic: This month Chris Pazsint will be talking about Agentic Coding. How does one use CLI Based Agents, and Agentic IDEs such as Cursor, Kiro, Antigravity? How to include agentic coding plugins for IDEs you already love such as Visual Studio Code. We meet on the last Monday of each Month. Presentations are given by members and friends of this group. If you would like to do a presentation (small or large) on a python topic, please contact Central OH Python at centralohpython@gmail.com

Welcome to Drunken Philosophy, a casual, curious, social discussion club. Come grab a drink and a seat at The Oracle. **Optional topic for this meetup: Where is everybody?** In 1950 the physicist Enrico Fermi was talking about aliens over lunch and asked a question that still has not gone away: if the universe is so vast and so old, and even a fraction of those billions of stars have planets, where is everyone? By the numbers the galaxy should be crowded with civilizations. Instead we look up and hear silence. That gap between "they should be everywhere" and "we see no one" is the Fermi Paradox. One of the most unsettling answers is the idea of a **Great Filter**: somewhere on the road from dead chemistry to a galaxy-spanning civilization, there is at least one step that is almost impossible to get past. Maybe the filter is behind us. Maybe life starting at all, or simple cells becoming complex, or intelligence ever evolving, is the freak accident, and we already cleared the hard part. Or maybe the filter is ahead of us, and advanced civilizations reliably wipe themselves out before they spread. Here is the part that messes with people. If we ever found life somewhere else, even pond scum on Mars, most people would call it the greatest discovery in history. But it might be the worst possible news. It would mean life is common, the early steps are easy, and the hard step is still in front of us. So the eerie silence overhead might actually be the best sign we could ask for. **Questions to wrestle with:** * Is it better to be alone? Would you rather we find alien life and learn we are not special, or find nothing and quietly improve our odds of surviving? * Where do you bet the filter sits, behind us or ahead of us, and why? * If it is ahead of us, what is it? Nuclear war, climate collapse, AI, something we cannot even picture yet? And can we do anything about a filter we cannot see coming? * Two principles pull opposite ways here. The principle of mediocrity (the Copernican principle, Sagan's "no privileged place in the universe") says we are ordinary, so what happened on Earth probably happened everywhere, which makes the silence scream louder. The anthropic principle says of course we find ourselves somewhere life was possible, since we could not observe anything else, so our being here may say almost nothing about how common life is. Which lens do you trust, and does the silence still demand an answer once you account for observer selection? * And if we did confirm life out there and had to accept we are not special, what would that do to belief in a higher power, and would shedding (or keeping) that belief help or hurt our odds of pulling together as one species? * Does any of this change how you live, or how humanity should be spending its time and money right now? As always the prompt is optional. Come for the conversation, stay for the drinks, and bring your own questions.

5:45-7:45 in Conference Room B, Library lower level. Bring your yarn projects, meet new friends. If you plan to attend, please RSVP yes. If you can’t attend, please change your RSVP to no. This helps anyone who is waitlisted and it allows me to have an accurate count of attendees as our space is quite limited. Plenty of parking in the lot, in the overflow lot across the street, and on the street. See you there!

**Important time note:** Please plan on arriving between 5:30 and 6:00 as the elevators lock after 6 and you'll need to message us and we'll need to come get you. The building address is 4450 Bridge Park The entrance is 6620 Mooney St, Suite 400 You will need to scan your ID at the door to get a visitor badge. **Abstract** *Customize the IDE: Building Extensions for Visual Studio Code* Visual Studio Code is one of the most widely used development environments today, and much of its flexibility comes from its extension ecosystem. Extensions allow developers to customize the editor with new features, integrations, and workflow improvements tailored to their needs. In this session, we’ll cover what extensions are and the different types available, including full extensions written in TypeScript or JavaScript, along with lighter-weight extensions such as color themes, language packs, language support, code snippets, and keymaps. We’ll also look at practical reasons a developer might create an extension, from automating repetitive tasks to adding custom tooling. The session includes a hands-on walkthrough of creating a new extension, testing it locally, and understanding the basic project structure. We’ll close with a brief overview of how extensions are packaged and published to the Visual Studio Marketplace and other distribution options. **YouTube Link** TBD

Our next much-awaited **COLUMBUS** meetup is **Tuesday June 30th from 7-10 pm EST at ACE OF CUPS**. Meet patients, cultivators, processors, dispensary managers/staff, physicians, home growers, educators, activists, nonprofits, artists, attorneys, business owners, writers, students, and supporters to network, share our knowledge, collaborate, support each other and make new ones! Hope you will be there too! Save the date and pass the word. **Please RSVP** so we know who is coming and how many to expect. Find us to say hi and we will introduce you to others. We should be easy to spot. (The happy-looking group wearing cool nametags! See photos from our past events.) Sign in, grab a name tag, start your own bar/food tab, meet old friends and make new ones! Everyone is welcome. SEE YOU THERE!