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Title: What Is Progress? Knowledge Aggregation, Living Textbooks, and the Automation of Scientific Discovery Date: June 20 2026 Noon - 14:00 EDT Summary: Our collective knowledge infrastructure — the textbooks, professional training resources, and literature syntheses that define what professionals across disciplines believe to be true — is quietly accruing a structural liability. Compounded confirmation bias, stacked citation-by-citation into the foundations of formal knowledge, means that breakthroughs can take decades to reach the classrooms, clinical workflows, and decision-making frameworks where they matter most. Meanwhile, the deepest friction is rarely acknowledged: before any field can build meaningful consensus on "why" or "how" a phenomenon occurs, it must first establish honest, consolidated agreement on "what" has actually been observed. That prior step is routinely skipped, assumed, or fragmented across siloed literatures that never cross-pollinate. This talk introduces a framework called "Knowledge Aggregation" — with two distinct but complementary ambitions. The first is descriptive transparency: algorithmically mapping what has been said, measured, and documented across a problem space, without imposing causal interpretation or narrative. The second traces the boundary between empirical observation and explanatory claim, building systems that can separate the "what" from the "why/how" — because consensus on mechanism cannot be meaningfully constructed until consensus on phenomenon is first established. Both ambitions are now within reach. By composing tools already at our disposal — large language models, classical NLP pipelines, public data repositories, and engineering-grade automation frameworks — it becomes possible to model knowledge itself, rather than merely imitate individual experts. One concrete expression of this is automating the writing of living textbooks: compressing the lag from bleeding-edge discovery, through replicated evidence, all the way to professional training resources. But the deeper aspiration reaches further — toward automating the discovery of scientific insights that have never previously been conceived, by systematically surfacing hypothesis combinations that no single siloed researcher would have had the cross-disciplinary vantage point to even ask. Drawing on ongoing systems biology and computational research — with ME/CFS research demoed as a use case for what siloed, fragmented knowledge infrastructure costs in practice — this talk maps the conceptual architecture, the real-world friction, and the data science toolkit for building it. Speaker: As a systems biologist at heart, Sam specializes his biomedical research on interactions and connections in biology - rather than just one domain of expertise. He wears many hats and collects skill sets across disciplines, with degree studies and industry experience acquired across Chemical Engineering (BSc), Bioinformatics (MSc), Systems and Synthetic Biology (M2), Biomedical Sciences (MSc), and beyond. Even more important to him than niches or fields of work, comes down to the synergistic approaches that allow us to move beyond reductionism. The notion that a question can only allow for one answer, is inherently reductionist. By resisting many norms in science and engineering which can get overly reductive, his current role as Principal Investigator of Research for DMV Petri Dish (501(c)(3) non-profit local to the DMV region) embraces computational frameworks that aide scale-up and automation - not only around the processes which already exist with established workflows, but also taking a keen interest in attempting and accomplishing ambitions which have never been perceived to be possible previously. Sam carries a passion for the synergy of computational biology - fused with wet lab validation. This way, one can build a beautiful knowledge base in the theoretical sense, and then test to see if said computational prediction might actually be able to stand in the real world with wet lab validation. Translational modeling starts to become possible once biological experiment design can be iteratively looped alongside computational model design, optimization, and analysis - empowering the design of a better wet lab experiment, followed by a better computational model, back and forth until science is done!

**GO TO EVENTBRITE FOR LINK TO MEETING:** https://www.eventbrite.com/e/recovering-from-religion-virtual-support-group-meeting-registration-159506756001?aff=oddtdtcreator This is an RfR-wide event, not tied to any particular local chapter. The Virtual Chapter Recovering From Religion support group will meet the the 1st Sunday of each month at 6 PM Central Time AS WELL AS at the 3rd Saturday of each month at 9 AM. This meeting will be held virtually via Zoom. Attendees are welcome to share, but may also decide to remain anonymous if they so choose. The primary focus of a Recovering From Religion support group is to provide ongoing and personal support to individuals as they let go of their religious beliefs. This transitional period is an ongoing process that can result in a range of emotions, as well as a ripple effect of consequences throughout an individual’s life. As such, the support meetings are safe and anonymous places to express these doubts, fears, and experiences without biased feedback or proselytizing. We are here to help each other through this journey. There is no cost to attend this support group but, if you feel so inclined, donations can be made at www.recoveringfromreligion.org/donate If you find you need to talk with someone before the meeting date, RfR has a hotline and online chat for that express purpose. Call (844) 368-2848 to speak with someone. Go to www.recoveringfromreligion.org and click on the green chat bubble in the lower left corner of the site to chat online. If you are in need of professional help, we can offer the Secular Therapy Project to provide options to connect with a professional therapist. All therapists have been thoroughly vetted by our organization and offer only evidence-based and non-religious treatment. Connect with them at www.seculartherapy.org. Like what RfR does? Why not volunteer! There are quite a few options. Head over to www.recoveringfromreligion.org/volunteer for more info.

This will be our kick-off meeting. Mostly, this is to get to know one another, and to figure out what everyone is looking for with the group and meetings. Newcomers to Linux and Free Software are always welcome, so please feel free to spread the word! Note, the room I was hoping to use in Wheaton is in extremely high demand, so this will be at the Silver Spring Library (Brigadier General Charles E. McGee Library), in Small Room 2. Unfortunately, parking is ***not*** free on Saturdays, and is $1.25/hour.

### Hopeful Cafe Conversations @Panera Kentlands **You are cordially invited to join in the conversation to catch the positive vibe... a cup of coffee, or another of your favorite refreshment.** **At NEW HOPE CAFE CONVERSATIONS on 3rd Saturdays, Monthly** **Address: Panera, 285 Kentlands Blvd., Gaithersburg, MD 20878** **Zoom Link: https://us06web.zoom.us/j/83326239362** ===== **New Hope Workshop**: What is Negativity Bias? How do we get ahead of it to reach more positive outcomes in work, life, and relationships? Discover the difference between goals and outcomes. 1\. How do we reaffirm ones role\, despite negativity bias from others? 2\. The New Hope Community Affirmative Statements of Foundational Principles 3\. Your Perspectives in Conversation **"Star Points Meal Deal"** If you have New Hope "Star Points 💫" you can get a discount on a meal. Also you can earn Star Points, if this is your first time attending Cafe Conversations, in-person. Ask Gene, newhope321community@yahoo.com, 240-848-0808.

Hey Poetry Lovers! This group is on a roll. Here’s the gist: We meet at the **Capital One Café in Chinatown** from **12pm - 2pm** every other week. For enrichment, we start by reading and reflecting on a **“published poem”**, suggested by someone in the group. No advance preparation is necessary. But feel free to check out some of the poems we’ve read [here](https://docs.google.com/spreadsheets/d/e/2PACX-1vSyE_wCLQCPHRrKmN5F9tOIeeRQUZESxjRXGVBoCF2uU8Gm0_d0uECiCBCQXEy6ksxfsBOhtRIOpW3T/pubhtml?gid=0&single=true&widget=true&headers=false%22%3E%3C/iframe%3E). Or submit suggestions for future meetings [here](https://docs.google.com/forms/d/e/1FAIpQLSexGc2Z2Kp6bZW0D3_hfJ7NUUkfNHf7TXX-43FglCeBd9EF2Q/viewform?usp=send_form). Next, we **share our work and offer feedback**. Depending on attendance, everyone gets \~10 minutes to use as they like. (No need to share, though; you’re welcome to come even if you prefer just to listen.) We maintain a **Discord server** to help share our work and communicate outside our bi-weekly meet-ups. If you haven’t used Discord before, take a moment to download it and create an account before arriving. When we meet you on Saturday, we will add you to our server, the “DC Poetry Workshop”, and can help you navigate the app if you have questions. Finally, if you plan on sharing a poem, consider how you will do so. Some options include: * Print 5-10 copies to distribute in person * Take and share screenshots in the Discord chat. * Copy the poem into a google doc, change sharing settings to “anyone with link”, and copy the google doc link into the Discord chat. Most importantly, we’re excited to meet you! Catch you on Saturday, Diego / Ian / Cayden / Nate / Otasha / Lia / An

We'll check out 29th Parallel Coffee in Fairfax Station. We plan to grab a coffee and head to Burke Lake Park and walk around the lake (weather permitting). There are a couple of parking areas at the park. I marked the parking we're planning to meet at the park. We hope to start the walk around 11:30AM. If you're a Fairfax County resident (with an ID), parking is free, otherwise they charge for parking. Please have a picture profile so we can recognize you in the meetup.

Come support Velocity's Monthly Warehouse Sale! We'll need help moving bicycles outside the warehouse before 9 a.m. and back inside at 1 p.m. In between, we'll greet customers, help them find bicycles and parts, and ring up their purchases on Square. Feel free to sign up even if you can't volunteer for the whole time. And remember to wear clothes you don't mind getting dirty with bicycle grease! Please note that volunteers under 18 are required to have a parent or guardian attend the beginning of their first volunteering session in order to sign a waiver for them, and volunteers under 16 are required to have a parent or guardian present with them during all the time they spend volunteering at Velocity.

Come join us for the weekly open mic night and enjoy a mix of comedy, poetry, and music!

Join us for a laid-back Sunday Brunch. The Brunch is All-You-Can-Eat buffet and a bottle of Champagne (750 ml) with Orange Juice. You make your own mimosa. Just only for $ 35.00 per person without tax & gratuity! It includes French toast, pancakes, waffles, omelettes made to order, Pasta, Salads, Roast Beef, Pork Ribs, oyster bar, cheese bar and Salmon, plenty of fresh fruit, yogurt, cakes, cookies, and pudding....mmmm! After brunch, we mingle and socialize. Closest Metro Station is Clarendon. Please take into account Metro's Weekend Track Work & Service Adjustments. Check it on http://www.wmata.com/ and plan accordingly.

Nice leisurely morning ride from Shirlington down to Alexandria Waterfront, then we'll stop for a yummy brunch at District Biscuit Company. Bring a bike lock. **++++++++++++++++++++** **The Ride: Summary** **(Must Read)** **++++++++++++++++++++** * RIDE NAME: Casual Brunch Group - District Biscuit * START LOC: Shirlington Library * START GPS: [https://goo.gl/maps/GXU2cMAG7672](https://goo.gl/maps/GXU2cMAG7672) * START PARKING: Any Garage in Shirlington * ARRIVAL: 9:00 am * SPEECH: 9:15 am * ROLLING: 9:30 am * LEVEL: Beginner * PACE: 10-12 mph * DISTANCE: \~12 miles * TERRAIN: Trail / Street / Cycle Tracks * RIDEWITHGPS: CBG_BRUNCH_BISCUIT_2026 * [https://ridewithgps.com/routes/47517809](https://ridewithgps.com/routes/47517809) **NOTES:** * We will meet in front of The Bearded Goat. * Ride is fairly flat. * Bring a bike lock. * It will be HOT- bring lots of ice water * Don't forget your $$, so you can have a yummy brunch. **++++++++++++++++++++** **The Ride: Detail** **++++++++++++++++++++** We will ride from Shirlington, to Four Mile Run Trail, to Mt Vernon Trail where we will head into Alexandria to hang out for a little bit at Waterfront Park. Once we are done checking out the waterfront we will head up Cameron to Commonwealth into Arlandria to District Biscuit Company. Their biscuits & breakfast sandwiches are delicious! They do offer a couple of gluten free items - eggs, meats, and a parfait; you should call ahead to check availability for the parfait because they don't always have it! Relax, eat, have fun, then back on bikes toward Four Mile Run to Shirlington. Total distance \~ approx. 12 miles. District Biscuit Company: [https://districtbiscuitco.com/](https://districtbiscuitco.com/) 3401 Mount Vernon Avenue Alexandria, Virginia 22305 **++++++++++++++++++++** **The Meeting Spot:** **++++++++++++++++++++** Shirlington Library 4200 Campbell Ave Arlington, VA 22206 GPS: [https://goo.gl/maps/GXU2cMAG7672](https://goo.gl/maps/GXU2cMAG7672) We will meet in front of The Bearded Goat. **++++++++++++++++++++** **The Ride After The Ride:** **++++++++++++++++++++** None. We just had brunch! **+++++++++++++++++++++** **Ride Level Chart** **+++++++++++++++++++++** NoVA CBG tries to accommodate all levels of cyclists by offering different types/levels of rides. We just ask that you come to the ride that suits your current riding ability the best. * Introductory Level: If you haven't ridden a bike in a number of years (or are uncertain of your abilities on a bicycle). * Beginner Level: You can ride for 10+ miles at a pace of 10+ to 12+ mph with potentially minor hills involved. * Medium Level: You can ride for 20+ miles at a pace of 13+ to 15+ mph with potentially moderate hills involved. * Advanced Level: You can ride for 20++ miles at a pace of 15+ mph with potentially major hills involved. Both Medium and Advanced Levels might require handling various challenges such as reading cue sheets, using a Garmin or navigation app, night riding, out of town travel, or any other odd cycling situations. **+++++++++++++++++++++** **The Fine Print:** **+++++++++++++++++++++** An RSVP of 'YES' is your digital signature and means you have read and understood MEETUP.com's: * "Terms of Service : Section 6. Release" found at https://www.meetup.com/terms/ * NOVA-CBG's "Assumption of Risk Agreement" found @ https://www.meetup.com/novacbg/pages/1942951/NOVA-CBG_Waiver/ * NoVA CBG's "COVID Policy" found @ http://bit.ly/2021_NoVACBG_COVID19_POLICY Helmets are required to participate in all NOVA-CBG rides. All riders ride at their own risk and with the understanding that cycling is an inherently dangerous activity. When coming to the meetup you do so voluntarily and are ready and able to participate in the ride as described under the conditions of the day. Be on time for the "pre-ride" preparation. If you do not attend the pre-ride preparation you will not be allowed to participate on the ride. There are NO exceptions to the above. ..........................................................................................................................

It's my birthday! Let's craft. We'll be meeting at Quill and Crumbs at the Shakespeare Folger Library in SE. The Shakespeare Folger Library is about 3 blocks from the Capitol South metro. Head up First as you get out of the station, pass the Library of Congress and the Capitol, turn right on East Capitol, and the Folger is on the right. The entrance is around the side, not through the front of the building. Head upstairs to the cafe and we'll be at the tables at the back. Bring your own cross stitch, knitting, crochet, or other portable craft.

Take a break from the busy week and join us at Llamabar Cafe for coffee, conversation, and community. 🦙 Expect a small, welcoming group, thoughtful discussions, and plenty of opportunities to connect with people beyond the usual week. Perfect for anyone who loves cafés, meeting new people, and leaving with a few new friends. 😊☕️

Come chat about Atlassian tools and best practices at the Reynoldsburg Sunny Street Cafe and Breakfast is on Atlassian! Let's get the day started off with breakfast with your ACE Leaders! We're always excited to talk about Atlassian Products, share our knowledge and hand out swag! Come chat with us about new product news and anything you are working on within the Atlassian product stack. This is a great opportunity to come see what we are all about, hear new business news and share with other Atlassian users your questions and experiences. We'd love to see new and old friends come out to chat and learn about Atlassian! Agenda --- Moderators Kimberly Deal - Columbus Atlassian User Group Leader Kevin Stanley - Columbus Atlassian User Group Leader Greg Sprowls - Columbus Atlassian Community Leader Hosted By Kimberly Deal, Atlassian User Group Leader Kevin Stanley, Chief Everything Greg Sprowls, Agility Lead --- Global Partner Atlassian (http://atlassian.com) Millions of users globally rely on Atlassian products every day for improving software development, project management, collaboration, and code quality. Partner Atlassian --- For over a decade, Atlassian customers have come together to network, share ideas, solve problems, and find new ways to use Atlassian products. Today, more than 15,000 people take part in Atlassian community events in more than 30 countries. --- Complete your event RSVP here: https://ace.atlassian.com/events/details/atlassian-columbus-presents-rise-and-shine-with-atlassian-reynoldsburg-5/.

Get ready for a Picnic, this is our social and member appreciation event for the year! Feel free to bring family, but be sure to reach out with the number of attendees, so we can provide food for everyone. There will of course be food, music, games and fun! Event is held rain or shine, we have a covered shelter house reserved for the event. Agenda --- Moderators Kimberly Deal - Columbus Atlassian User Group Leader Kevin Stanley - Columbus Atlassian User Group Leader Greg Sprowls - Columbus Atlassian Community Leader Hosted By Kimberly Deal, Atlassian User Group Leader Kevin Stanley, Chief Everything Greg Sprowls, Agility Lead --- Global Partner Atlassian (http://atlassian.com) Millions of users globally rely on Atlassian products every day for improving software development, project management, collaboration, and code quality. For over a decade, Atlassian customers have come together to network, share ideas, solve problems, and find new ways to use Atlassian products. Today, more than 15,000 people take part in Atlassian community events in more than 30 countries. --- Complete your event RSVP here: https://ace.atlassian.com/events/details/atlassian-columbus-presents-annual-columbus-ace-summer-picnic/.

We are bringing Microsoft Build sessions to Columbus Ohio! The Central Ohio Azure Meetup and Central Ohio .NET Developer's Group (CONDG) are coming together to bring some of the labs and breakouts from Microsoft Build to your backyard. In this free, 1 day event, you are going to Build stuff with us! And yes, there will be free food. Please RSVP via [Microsoft Build //localhost:columbus | Microsoft Reactor](https://developer.microsoft.com/en-us/reactor/events/27247/).

**Important time note:** Please plan on arriving between 5:30 and 6:00 as the elevators lock after 6 and you'll need to message us and we'll need to come get you. The building address is 4450 Bridge Park The entrance is 6620 Mooney St, Suite 400 You will need to scan your ID at the door to get a visitor badge. **Abstract** *Customize the IDE: Building Extensions for Visual Studio Code* Visual Studio Code is one of the most widely used development environments today, and much of its flexibility comes from its extension ecosystem. Extensions allow developers to customize the editor with new features, integrations, and workflow improvements tailored to their needs. In this session, we’ll cover what extensions are and the different types available, including full extensions written in TypeScript or JavaScript, along with lighter-weight extensions such as color themes, language packs, language support, code snippets, and keymaps. We’ll also look at practical reasons a developer might create an extension, from automating repetitive tasks to adding custom tooling. The session includes a hands-on walkthrough of creating a new extension, testing it locally, and understanding the basic project structure. We’ll close with a brief overview of how extensions are packaged and published to the Visual Studio Marketplace and other distribution options. **YouTube Link** TBD

**Presenter:** Matthew Hess, Microsoft MVP **Time:** Pizza at 6:00, Presentation Starts at 6:30pm Eastern **Location:** Theoris, 9000 Keystone Crossing, Either Downstairs or in Suite 230 if main meeting room isn't available, Indianapolis In 2019 (C# 8.0) Microsoft introduced a feature that has generated a lot of confusion, debate and outright dissent. I'm talking about Nullable Reference Types. In this presentation, I we dig into this feature, explore why it exists, what problem it tries to solve, how it works, and how people have critiqued it, so that you as a programmer can decide if and how you want to use it. Looking forward to seeing you there!

Columbus Code & Coffee is an inclusive, informal co-working session. People of all skill levels attend, and we love it that way. Many people (optionally) bring projects to work on, and many other people (optionally) socialize the entire time. It's entirely up to you! **What to Expect at the Intro Circle** \~\~\~\~\~\~\~\~\~\~\~\~\~ Near the beginning of the event (1:30 pm), we do a standup: * Organizer announcements, updates, and logistics Round 1 - (7 secs max): * Your name * What you're working on * What you can help others with Round 2: * Community events you wanna plug. If none, that's cool too. Round 3: * Job opportunities you're hiring for OR announce that you are looking for one. If none, that's cool. After the introduction circle, everything is self-organized! Feel free to work alone, pair up, attend one of our workshops/presentations, or mingle!

We are going to build together with all the CLIs! E will be doing it at Columbus Code and Coffee Agenda --- Hosted By James Power, Organizer Pete Gordon, Organizer Just a Software Guy in the age of the Internet. Complete your event RSVP here: https://gdg.community.dev/events/details/google-gdg-columbus-presents-ai-improv-lets-build-a-game-together-with-claude-code-codex-and-gemini-and-be-the-judge/.