High Scalability Computing

Title: What Is Progress? Knowledge Aggregation, Living Textbooks, and the Automation of Scientific Discovery Date: June 20 2026 Noon - 14:00 EDT Summary: Our collective knowledge infrastructure — the textbooks, professional training resources, and literature syntheses that define what professionals across disciplines believe to be true — is quietly accruing a structural liability. Compounded confirmation bias, stacked citation-by-citation into the foundations of formal knowledge, means that breakthroughs can take decades to reach the classrooms, clinical workflows, and decision-making frameworks where they matter most. Meanwhile, the deepest friction is rarely acknowledged: before any field can build meaningful consensus on "why" or "how" a phenomenon occurs, it must first establish honest, consolidated agreement on "what" has actually been observed. That prior step is routinely skipped, assumed, or fragmented across siloed literatures that never cross-pollinate. This talk introduces a framework called "Knowledge Aggregation" — with two distinct but complementary ambitions. The first is descriptive transparency: algorithmically mapping what has been said, measured, and documented across a problem space, without imposing causal interpretation or narrative. The second traces the boundary between empirical observation and explanatory claim, building systems that can separate the "what" from the "why/how" — because consensus on mechanism cannot be meaningfully constructed until consensus on phenomenon is first established. Both ambitions are now within reach. By composing tools already at our disposal — large language models, classical NLP pipelines, public data repositories, and engineering-grade automation frameworks — it becomes possible to model knowledge itself, rather than merely imitate individual experts. One concrete expression of this is automating the writing of living textbooks: compressing the lag from bleeding-edge discovery, through replicated evidence, all the way to professional training resources. But the deeper aspiration reaches further — toward automating the discovery of scientific insights that have never previously been conceived, by systematically surfacing hypothesis combinations that no single siloed researcher would have had the cross-disciplinary vantage point to even ask. Drawing on ongoing systems biology and computational research — with ME/CFS research demoed as a use case for what siloed, fragmented knowledge infrastructure costs in practice — this talk maps the conceptual architecture, the real-world friction, and the data science toolkit for building it. Speaker: As a systems biologist at heart, Sam specializes his biomedical research on interactions and connections in biology - rather than just one domain of expertise. He wears many hats and collects skill sets across disciplines, with degree studies and industry experience acquired across Chemical Engineering (BSc), Bioinformatics (MSc), Systems and Synthetic Biology (M2), Biomedical Sciences (MSc), and beyond. Even more important to him than niches or fields of work, comes down to the synergistic approaches that allow us to move beyond reductionism. The notion that a question can only allow for one answer, is inherently reductionist. By resisting many norms in science and engineering which can get overly reductive, his current role as Principal Investigator of Research for DMV Petri Dish (501(c)(3) non-profit local to the DMV region) embraces computational frameworks that aide scale-up and automation - not only around the processes which already exist with established workflows, but also taking a keen interest in attempting and accomplishing ambitions which have never been perceived to be possible previously. Sam carries a passion for the synergy of computational biology - fused with wet lab validation. This way, one can build a beautiful knowledge base in the theoretical sense, and then test to see if said computational prediction might actually be able to stand in the real world with wet lab validation. Translational modeling starts to become possible once biological experiment design can be iteratively looped alongside computational model design, optimization, and analysis - empowering the design of a better wet lab experiment, followed by a better computational model, back and forth until science is done!

This will be our kick-off meeting. Mostly, this is to get to know one another, and to figure out what everyone is looking for with the group and meetings. Newcomers to Linux and Free Software are always welcome, so please feel free to spread the word! Note, the room I was hoping to use in Wheaton is in extremely high demand, so this will be at the Silver Spring Library (Brigadier General Charles E. McGee Library), in Small Room 2. Unfortunately, parking is ***not*** free on Saturdays, and is $1.25/hour.

🎭 DMV Mystery & Social Game Night! 🍦 Looking for a fun, social way to spend your Saturday? Join us for a mix of Secret Hitler, Mafia, and murder mystery games — no experience needed, just bring your sense of humor! 🗓️ Every 3rd Saturday @ 4 PM 📍 Meridian at Eisenhower 🍨 Snacks, ice cream, and good vibes provided 👥 Hosts: Terry (626) 679-5001 & Nishant (914) 473-0481 Come solo or with friends — we’ll make sure you feel welcome and included. 😄 Fun games • New friends • Great energy

Join us to commemorate the 250th anniversary of the United States at Indepen’Dance! With activities for all ages, Indepen’Dance! celebrates the nation’s history and culture through the lens of dance, illuminating the ways dance contributes to individuality, creativity, and our shared identity. Big band/swing dance party with Scott Silbert’s Biggest Big Band 4:00-6:00 p.m. Madison Drive Terrace Enjoy a roaring, energetic, and unforgettable swing dancing experience with Scott Silbert’s Biggest Big Band. The group expands beyond the standard big band by adding a full string section to create a dynamic and lush swing-era sound and resurrects the distinctive styles of legendary bandleaders like Jimmie Lunceford, Chick Webb, Count Basie, Fletcher Henderson, Benny Goodman, and others. Enjoy a roaring, energetic, and unforgettable swing dancing experience. https://americanhistory.si.edu/events/calendar/independance-big-bandswing-dance-party-scott-silberts-biggest-big-band

Hey Poetry Lovers! This group is on a roll. Here’s the gist: We meet at the **Capital One Café in Chinatown** from **12pm - 2pm** every other week. For enrichment, we start by reading and reflecting on a **“published poem”**, suggested by someone in the group. No advance preparation is necessary. But feel free to check out some of the poems we’ve read [here](https://docs.google.com/spreadsheets/d/e/2PACX-1vSyE_wCLQCPHRrKmN5F9tOIeeRQUZESxjRXGVBoCF2uU8Gm0_d0uECiCBCQXEy6ksxfsBOhtRIOpW3T/pubhtml?gid=0&single=true&widget=true&headers=false%22%3E%3C/iframe%3E). Or submit suggestions for future meetings [here](https://docs.google.com/forms/d/e/1FAIpQLSexGc2Z2Kp6bZW0D3_hfJ7NUUkfNHf7TXX-43FglCeBd9EF2Q/viewform?usp=send_form). Next, we **share our work and offer feedback**. Depending on attendance, everyone gets \~10 minutes to use as they like. (No need to share, though; you’re welcome to come even if you prefer just to listen.) We maintain a **Discord server** to help share our work and communicate outside our bi-weekly meet-ups. If you haven’t used Discord before, take a moment to download it and create an account before arriving. When we meet you on Saturday, we will add you to our server, the “DC Poetry Workshop”, and can help you navigate the app if you have questions. Finally, if you plan on sharing a poem, consider how you will do so. Some options include: * Print 5-10 copies to distribute in person * Take and share screenshots in the Discord chat. * Copy the poem into a google doc, change sharing settings to “anyone with link”, and copy the google doc link into the Discord chat. Most importantly, we’re excited to meet you! Catch you on Saturday, Diego / Ian / Cayden / Nate / Otasha / Lia / An

We'll check out 29th Parallel Coffee in Fairfax Station. We plan to grab a coffee and head to Burke Lake Park and walk around the lake (weather permitting). There are a couple of parking areas at the park. I marked the parking we're planning to meet at the park. We hope to start the walk around 11:30AM. If you're a Fairfax County resident (with an ID), parking is free, otherwise they charge for parking. Please have a picture profile so we can recognize you in the meetup.

We play a variety of games with a focus on high interaction Euros. Events will start with quick games while people arrive and eat lunch. We will start longer games between 1:30pm and 2pm. While the official end time is 5pm, people are welcome to continue playing games afterwards. Western Market closes at 7pm on Sundays. This page has more examples of high interaction Euros: [Old-school German-style Games](https://boardgamegeek.com/guild/view/3948). Here are some games that have been played at past events: High Interaction Euros * [Medici](https://boardgamegeek.com/boardgame/46/medici) * [Catan](https://boardgamegeek.com/boardgame/13/catan) * [Hansa Teutonica](https://boardgamegeek.com/boardgame/43015/hansa-teutonica) * [Puerto Rico](https://boardgamegeek.com/boardgame/3076/puerto-rico) * [Concordia](https://boardgamegeek.com/boardgame/124361/concordia) * [Power Grid](https://boardgamegeek.com/boardgame/2651/power-grid) * [Brass: Birmingham](https://boardgamegeek.com/boardgame/224517/brass-birmingham) Other high interaction games * [Innovation](https://boardgamegeek.com/boardgame/63888/innovation) * [Imperial](https://boardgamegeek.com/boardgame/24181/imperial) There are a variety of food and drink options. Western Market is allowing us to use the space for free. Please reciprocate by purchasing something, even if it is just a soda. Directions If you're taking the Orange, Silver, or Blue lines, exit at the Foggy Bottom metro station and walk two blocks to the east. If you are taking the Red Line, Farragut North is an approximately a 15 minute walk away. There is also free street parking to the north.

Please bring a nutritarian dish or salad to share with at least 8 members. Also, you could bring containers to take home etras at the end of the evening. We will share resouces, recipes and other info as we support each other in choosing high nutrient dense eating.

NOTE: This working session is at West End Neighbourhood Library not MLK. It is near the Foggy Bottom Metro Station. A game development **Working Session** involves 3 key parts: 1. Tell people what you're going to do 2. Actually do stuff 3. Show people what you did **What to bring**: Laptop, Charger, maybe a power strip if you have one handy, any other game development tools you need. Try to download any software you need before the working session. There is Wifi at this location, but it may be slow if you have to download any large files.

It's my birthday! Let's craft. We'll be meeting at Quill and Crumbs at the Shakespeare Folger Library in SE. The Shakespeare Folger Library is about 3 blocks from the Capitol South metro. Head up First as you get out of the station, pass the Library of Congress and the Capitol, turn right on East Capitol, and the Folger is on the right. The entrance is around the side, not through the front of the building. Head upstairs to the cafe and we'll be at the tables at the back. Bring your own cross stitch, knitting, crochet, or other portable craft.

This offering, *Rest. Restore. Reconnect: When Slowing Down Feels Hard*, was born from a truth I know intimately — that rest isn’t always easy. That stillness can feel unfamiliar. That slowing down can bring us face-to-face with everything we’ve been carrying. **And yet… it’s also where the healing begins.** **[REGISTER HERE](https://www.eventbrite.com/e/rest-restore-reconnect-3-week-yin-restorative-popup-yoga-experience-tickets-1988229785811?aff=oddtdtcreator)** **DROP INS: $20.00 PER SESSION** **ALL THREE SESSIONS: $60.00** **TWO FOR ONE ALL THREE SESSIONS: $70.00 (invite a friend)** **DATES: Saturday, June 13, Saturday, June 20, and Saturday, June 27** **TIMES: 10 AM - 11 AM** Over the course of three Saturdays, we’ll gather in a space at the **Black Owned Teahouse: [Adjourn Teahouse](https://adjournteahouse.com) in Lanham, MD,** intentionally curated for softness, support, and gentle return. Through yin + restorative yoga therapy, you’ll be guided to release tension, regulate your nervous system, and reconnect with your body in a way that feels safe and sustainable. This is not about doing more. This is about allowing yourself to *be*. And because your experience matters beyond the mat, each session will close with a beautiful tea time — a moment to integrate, connect, and savor. There will be other thoughtful touches woven throughout… little surprises to deepen your experience and make each gathering feel like a retreat from the noise of everyday life. If you’ve been feeling stretched, overwhelmed, or disconnected… If your body has been asking you to slow down, but you haven’t known how… This space was created with you in mind. **[REGISTER HERE](https://www.eventbrite.com/e/rest-restore-reconnect-3-week-yin-restorative-popup-yoga-experience-tickets-1988229785811?aff=oddtdtcreator)** **DROP INS: $20.00 PER SESSION** **ALL THREE SESSIONS: $60.00** **TWO FOR ONE ALL THREE SESSIONS: $70.00 (invite a friend)** **DATES: Saturday, June 13, Saturday, June 20, and Saturday, June 27** **TIMES: 10 AM - 11 AM** ALL ARE WELCOMED Limited spots available — because intimacy, presence, and care are at the heart of this experience. I can’t wait to hold space for you 🌿✨

We will be meeting in the Wilson Room. For June, we will be reading Excellent Women by Barbara Pym. A paperback version runs 231 pages. It was published in 1952. The GoodReads blurb is One of Barbara Pym’s richest and most amusing high comedies, *Excellent Women* has at its center Mildred Lathbury, a clergyman’s daughter and a mild-mannered spinster in 1950s England. She is one of those “excellent women,” the smart, supportive, repressed women who men take for granted. As Mildred gets embroiled in the lives of her new neighbors—anthropologist Helena Napier and her handsome, dashing husband, Rocky, and Julian Malory, the vicar next door—the novel presents a series of snapshots of human life as actually, and pluckily, lived in a vanishing world of manners and repressed desires.

We are bringing Microsoft Build sessions to Columbus Ohio! The Central Ohio Azure Meetup and Central Ohio .NET Developer's Group (CONDG) are coming together to bring some of the labs and breakouts from Microsoft Build to your backyard. In this free, 1 day event, you are going to Build stuff with us! And yes, there will be free food. Please RSVP via [Microsoft Build //localhost:columbus | Microsoft Reactor](https://developer.microsoft.com/en-us/reactor/events/27247/).

We are a real world Martial arts group. \ Called DO JUNG ISHU (the art of fighting) \ Based off of Jeet kune do we just continued where Bruce Lee left off. \ We have been around a while. \ Every week we get together and work technical skills and full contact spar. \ Almost all of the instructors have been in everything from street fights to the ring and some still compete in cage fighting. \ If you want to take your skills up, improve your confidence, gain self defense skills, get in better shape, test yourself or just want to kill some time and possibly get hit a bit come on down. \ We will be located at 3923 N High St, Columbus, OH 43214 Outside in the grass between the playground and horseshoe area. our instructors are normally in a black and red art of fighting shirt \ if you can not find us call or text me at 6143570295 Saturday 1:30pm Wednesday 5:45pm From Age 16 and up. attendees under the age of 18 must have a guardian with them. \ Wear workout clothes. \ Bring a MOUTHPIECE! \ WE HAVE GLOVES. \ $10 per class $5 per class if you are wearing a club shirt Club shirts are $25 Hope to see you soon. \ let me know if you have any questions :)

**Improving Office in Franklinton** Physical location: Improving Office 330 Rush Alley Suite #150 Columbus, OH 43215 Schedule: 6:00 p.m.: Socialize, eat, and drink. Improving will be providing pizza and beverages. 6:30 to 8:00 pm. Main meeting and presentation(s). Topic: This month Chris Pazsint will be talking about Agentic Coding. How does one use CLI Based Agents, and Agentic IDEs such as Cursor, Kiro, Antigravity? How to include agentic coding plugins for IDEs you already love such as Visual Studio Code. We meet on the last Monday of each Month. Presentations are given by members and friends of this group. If you would like to do a presentation (small or large) on a python topic, please contact Central OH Python at centralohpython@gmail.com

We are a real world Martial arts group. \ Called DO JUNG ISHU (the art of fighting) \ Based off of Jeet kune do we just continued where Bruce Lee left off. \ We have been around a while. \ Every week we get together and work technical skills and full contact spar. \ Almost all of the instructors have been in everything from street fights to the ring and some still compete in cage fighting. \ If you want to take your skills up, improve your confidence, gain self defense skills, get in better shape, test yourself or just want to kill some time and possibly get hit a bit come on down. \ We will be located at 3923 N High St, Columbus, OH 43214 Outside in the grass between the playground and horseshoe area. our instructors are normally in a black and red art of fighting shirt \ if you can not find us call or text me at 6143570295 Saturday 1:30pm Wednesday 5:45pm From Age 16 and up. attendees under the age of 18 must have a guardian with them. \ Wear workout clothes. \ Bring a MOUTHPIECE! \ WE HAVE GLOVES. \ $10 per class $5 per class if you are wearing a club shirt Club shirts are $25 Hope to see you soon. \ let me know if you have any questions :)

**Important time note:** Please plan on arriving between 5:30 and 6:00 as the elevators lock after 6 and you'll need to message us and we'll need to come get you. The building address is 4450 Bridge Park The entrance is 6620 Mooney St, Suite 400 You will need to scan your ID at the door to get a visitor badge. **Abstract** *Customize the IDE: Building Extensions for Visual Studio Code* Visual Studio Code is one of the most widely used development environments today, and much of its flexibility comes from its extension ecosystem. Extensions allow developers to customize the editor with new features, integrations, and workflow improvements tailored to their needs. In this session, we’ll cover what extensions are and the different types available, including full extensions written in TypeScript or JavaScript, along with lighter-weight extensions such as color themes, language packs, language support, code snippets, and keymaps. We’ll also look at practical reasons a developer might create an extension, from automating repetitive tasks to adding custom tooling. The session includes a hands-on walkthrough of creating a new extension, testing it locally, and understanding the basic project structure. We’ll close with a brief overview of how extensions are packaged and published to the Visual Studio Marketplace and other distribution options. **YouTube Link** TBD

**Latest Dojo Location!** **Knotty Pine Brewing** 1765 W 3rd Ave, Columbus, OH 43212 We're going to try a new dojo location for a few weeks and see how it works Dojos are informal Python group study sessions where everyone interested in Python gathers to learn about Python, help others with Python, or just hang out. Everyone is welcome from Python beginners to experts. Bringing a laptop is encouraged (we'll have extension cords and power strips). If there's something you want to learn leave a comment on this invite so we can plan ahead. We're looking for speakers for our Monthly Meetups! Fill out the form if you are interested in presenting to the Python Community. https://forms.gle/ehSfUAC2WgR34Crq9

Most people still use AI like a search box: type one question, get one answer, repeat. But the next step is AI agents: systems that can take a goal, break it into steps, use tools, remember context, and produce useful work for a human to review. In this beginner-friendly session, we’ll demystify what AI agents actually are — without hype or jargon. We’ll walk through practical examples of how agents can help with research, planning, writing, coding, operations, and personal productivity. We’ll cover: * What makes an AI “agent” instead of just a chatbot * How agents break tasks into steps * Where agents are genuinely useful today * Where they fail, hallucinate, or need human review * How to design simple AI workflows for your own work * A live demo of an AI agent-style workflow from start to finish No coding experience required. This is for anyone who wants to understand where AI tools are going and how to use them more effectively right now. LOGISTICS AND PARKING: The talk starts at 7:00 PM. The first half hour is reserved for everyone to get set up and mingle. Free pizza and drinks! The cheapest parking option is to find street parking, which will only cost you a few bucks. Otherwise, park in the nearby veteran's museum lot for $8. It's highly recommended you avoid the nearby $15 garage parking.